Accelerated surgery for hip fractures in patients with heart injury

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The HIP ATTACK-2 trial is an international, multicenter, randomized controlled trial designed to evaluate the effectiveness of accelerated surgical treatment for hip fractures in patients who also have acute myocardial injury. Participants will be randomly assigned to receive either accelerated surgery or standard care, with the primary goal of reducing mortality at 90 days post-randomization. Secondary outcomes will include assessments of mobility, complications, delirium, length of hospital stay, pain levels, and quality of life. The trial aims to provide insights into the optimal management of hip fractures in this vulnerable patient population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. age ≥45 years;
2. diagnosis of hip fracture during working hours with a low-energy mechanism requiring surgery;
3. troponin elevation ( at least one troponin measurement above the upper limit of normal occurring from the time of hip fracture to the time of randomization); and
4. informed consent.

Exclusion Criteria:

1. taking a therapeutic dose of an anticoagulant for which no reversing agent is available and the anesthesiologist or surgeon believe surgery within 6 hours of eligibility criteria met would not be safe;
2. patients on a therapeutic vitamin K antagonist with a history of heparin induced thrombocytopenia (HIT);
3. patients with peri-prosthetic fracture, open fracture or bilateral fractures;
4. patients requiring an emergency surgery for another reason (e.g., subdural hematoma);
5. patients with acute myocardial infarction deemed to be clinically unstable, with a mechanical complication (i.e., acute papillary muscle rupture, ventricular septal defect), ST elevation myocardial infarction, or cardiogenic shock;
6. patients refusing consent; or
7. patients previously enrolled in HIP ATTACK-2.

Where it's running

• The John Hunter Hospital
  New Lambton Heights, New South Wales, Australia Recruiting
• University of São Paulo
  São Paulo, São Paulo, Brazil Recruiting
• St. Joseph's Healthcare Hamilton
  Hamilton, Ontario, Canada Recruiting
• Juravinski Hospital
  Hamilton, Ontario, Canada Recruiting
• Victoria Hospital
  London, Ontario, Canada Recruiting
• Markham Stouffville Hospital
  Markham, Ontario, Canada Recruiting

+27 more sites. See ClinicalTrials.gov for the full list.

Study contacts

• Principal investigator: Flavia Borges, M.D — Population Health Research Institute
• Study coordinator: Valerie Harvey
• Email: valerie.harvey@phri.ca
• Phone: 905-297-3479

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Understanding heart artery disease using biomarkers and imaging in Oxford

  Researchers in Oxford are testing how biomarkers and advanced imaging can help explain why some heart artery plaques are unstable and how this affects heart damage after a heart attack.

  Recruiting University of Oxford · Oxford · NCT07772570

• Patient-centered education after hip fracture surgery

  A structured education program after hip fracture surgery is being tested to see if it helps patients recover better than routine care alone.

  Recruiting Assiut University · Qina, Qena Governorate · NCT07739225

• PENG Block Compared with Femoral Nerve Block for Spinal Anesthesia in Hip Fracture Surgery

  This trial tests whether the ultrasound-guided Pericapsular Nerve Group (PENG) block helps when positioning for spinal anesthesia in older adults with hip fractures, compared with the standard femoral nerve block.

  Recruiting Taksim Egitim ve Arastirma Hastanesi · Istanbul, Beyoglu and 1 other locations · NCT07717463

• French version validation of the New Mobility Score for older adults after hip fracture

  This study tests whether the French version of the New Mobility Score accurately measures mobility in French patients aged 75 and older after hip fracture.

  Recruiting Hospices Civils de Lyon · Lyon · NCT07622095

• One versus two doses of tranexamic acid for hip fracture surgery

  This will test whether giving one dose or two doses of tranexamic acid around surgery helps people aged 65 and older with pertrochanteric or subtrochanteric hip fractures lose less blood and need fewer transfusions.

  Recruiting University Hospital for Surgical Diseases St. Naum Ohridsk i- Skopje · Skopje · NCT07432737

• PENG block plus local infiltration analgesia for anterior-approach hip replacement

  This test sees if a motor-sparing PENG block combined with local infiltration around the hip controls pain as well as spinal anesthesia for adults having anterior‑approach hip replacement.

  Recruiting ASST Gaetano Pini-CTO · Milan · NCT07239817

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.