Ablation and pacing for patients with atrial fibrillation
Official title: Safety and Efficacy of Distal His Bundle Pacing Compared to Right Ventricular Pacing in Patients With Symptomatic Atrial Fibrillation Undergoing AV Node Ablation With Evidence of Heart Failure, a Randomised Control Study
Run by University Hospitals, Leicester · NCT06152406 · Data updated 2026-11-12
This study is testing whether a new type of heart pacing can help people with atrial fibrillation feel better compared to traditional pacing after they have a procedure to control their heart rhythm.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 100 Years |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | University Hospitals, Leicester Academic / other |
| Locations | 1 site (Leicester, Leicestershire) |
| Status | Recruiting |
| Started | October 24, 2023 |
| Main results expected | February 29, 2028 |
| Study ends | February 29, 2028 |
| Registry record updated | January 5, 2026 |
| Trial ID | NCT06152406 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18 and older with symptomatic atrial fibrillation who are not suitable for rhythm control strategies and require AV node ablation.
✕Probably not a fit
Patients who already have a pacemaker or those with severe left ventricular systolic dysfunction may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
The Ablate and Pace HIS Study is a prospective randomized trial focusing on patients with symptomatic atrial fibrillation who are not suitable for rhythm control strategies. It aims to compare the outcomes of traditional right ventricular pacing against HIS bundle pacing in patients undergoing AV node ablation and pacemaker implantation. A total of 100 participants will be randomized into two groups, with endpoint measurements taken at multiple time points to assess the effectiveness of HIS pacing. The study is designed to be double-blinded to ensure unbiased results.
Why it matters
Potential benefit: If successful, this study could improve the quality of life for patients with atrial fibrillation by providing a more effective pacing strategy.
How similar studies have gone: Previous studies have shown promising results with HIS bundle pacing, indicating potential benefits over traditional pacing methods.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Aged 18 or above * Symptomatic AF, New York Heart Association (NYHA) class II-IV * Willing to consent for the study * AF regardless type, deemed not suitable for rhythm control strategy that has been referred for AVN ablation with one of the following: 1. Impaired LV function, EF \<50 %. And or 2. Raised N-Terminal Pro B-type Natriuretic Peptide ( NT-ProBNP) \>365 ng/L Exclusion Criteria: * Patient who has already got a pacemaker in situ * Known severe LVSD when biventricular device is the thought to be the preferred pacing modality * Females in child bearing period * Lack of capacity to consent * Other serious medical condition with life expectancy of less than 1 year * Less than 18 years * Unwilling to consent for the study
Where it's running
-
University Hospitals of Leicester NHS Trust
Leicester, Leicestershire, United Kingdom Recruiting
Study contacts
- Study coordinator: Mokhtar Ibrahim, Dr
- Email: mokhtar.ibrahim@uhl-tr.nhs.uk
- Phone: 0116 2583887
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
AI-based tools to help diagnose, treat and predict stroke outcomes across multiple hospitals
This study tests AI-powered tools on real-world stroke patients to see if they can improve pre-hospital triage, diagnosis, and outcome prediction while data stay securely within each hospital.
-
Left-atrial Fibrosis in Persistent Atrial Fibrillation and Its Comorbidities
This study tests how comorbid conditions like sleep apnea and primary aldosteronism relate to left-atrial fibrosis and AF recurrence in patients undergoing ablation.
-
Dual Energy ablation with SmartTouch SF catheter in persistent atrial fibrillation
This study tests a pulsed field and radiofrequency ablation system to treat persistent atrial fibrillation in adults who have not responded well to prior medications.
-
Identifying AF patients who may need more than standard ablation using Volta AF-Xplorer II
This trial tests whether AI-identified dispersion areas during AF ablation can predict recurrence after a standard pulmonary vein isolation in patients with persistent AF.
-
4D intracardiac echocardiography to guide left atrial appendage occlusion procedures
A new 4D ICE catheter is being tested alongside standard imaging to see if it can safely guide left atrial appendage occlusion procedures for adults with atrial fibrillation.
-
Thoracoscopic vs Catheter Ablation as the First Rhythm Control in Atrial Fibrillation with a Large Left Atrium
This trial tests whether thoracoscopic surgical ablation is better at keeping atrial fibrillation under control than catheter ablation in people with persistent AF and a large left atrium who have not had an ablation before.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.