A universal primary care approach to reduce youth overdose risk
Official title: A Universal Primary Care Based Intervention to Reduce Youth Overdose Risk Aim 3
Run by Boston Medical Center · NCT07797933 · Data updated 2026-11-12
A brief overdose-prevention education program is being tested in pediatric primary care to see if it helps youth ages 13–26 recognize and respond to overdoses better than usual care.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 13 Years and up |
| Sex | All |
| Enrollment | 648 (estimated) |
| Sponsor | Boston Medical Center Academic / other |
| Locations | 1 site (Boston, Massachusetts) |
| Status | Recruiting |
| Started | November 2026 |
| Main results expected | August 2029 |
| Study ends | August 2029 |
| Registry record updated | November 10, 2026 |
| Trial ID | NCT07797933 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are youth aged 13–26 attending participating primary care clinics and able to speak English or Spanish, with providers willing to deliver the intervention.
✕Probably not a fit
Some participants may not benefit if they do not engage with the education or if it is not applicable to their risk factors.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This randomized trial tests a brief, universal overdose prevention education delivered in pediatric primary care settings. It targets youth aged 13 to 26 and involves several clinics in Massachusetts. Providers (physicians and advanced practice clinicians) will deliver the intervention during routine visits, with comparison to usual care. The study aims to see whether the education improves overdose awareness and response skills among youth, potentially reducing overdose harm. Enrollment requires participating clinics and English- or Spanish-speaking youth and excludes those with specific language or consent barriers.
Why it matters
Potential benefit: If successful, youth may have improved knowledge and skills to prevent overdose and respond effectively in overdose situations.
How similar studies have gone: Previous efforts in similar settings are limited for pediatric primary care overdose prevention, making this a relatively novel approach with potential for informative results.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: Providers: * Physicians and advanced practice providers (nurse practitioners and physician assistants) within Pediatric Primary Care and Family Medicine at Boston Medical Center, NeighborHealth, and South Boston Community Health Center * ≥ 1 clinic session per week Youth: * Ages 13 - 26 * Scheduled for a comprehensive physical exam (CPE) or follow-up clinical appointment with a provider who is participating in the trial * English or Spanish speaking Exclusion Criteria: Providers: * Participated as an intervention provider in the R61 pilot RCT (H-45731) * Participated in the Community Advisory Board that assisted in the development of the intervention (H-45388) Youth: * Caregivers of youth ages 13-17 unable to provide informed consent or are not English speaking * Cognitive limitation or intellectual disability that in the opinion of their provider would not be able to complete the requirements of the research * Young adults ages 18-26 with a legal guardian * Any medical/psychiatric condition that causes acute distress and requires emergency evaluation * Under legal custody of the Department of Children and Families (DCF) * Participated in the intervention arm of the R61 pilot RCT (H-45731)
Where it's running
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Boston Medical Center
Boston, Massachusetts, United States Recruiting
Study contacts
- Principal investigator: Sarah Bagley, MD — Boston Medical Center, Internal Medicine, Addiction Medicine
- Study coordinator: Sarah Bagley, MD, MSc
- Email: sarah.bagley@bmc.org
- Phone: (617) 414-7399
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.