A Study of Nivolumab in Participants With Hepatocellular Carcinoma Who Are at High Risk of Recurrence After Curative Hepatic Resection or Ablation

Who can join: the full rules

Inclusion Criteria:

* Participants with a first diagnosis of HCC who have undergone a curative resection or ablation
* Participants are eligible to enroll if they have non-viral related-HCC, or if they have HBV-HCC, or HCV-HCC
* Child-Pugh Score 5 or 6
* Eastern Cooperative Oncology Group (ECOG) performance status (PS) 0 or 1

Exclusion Criteria:

* Known fibrolamellar HCC, sarcomatoid HCC, or mixed cholangiocarcinoma and HCC
* Any evidence of tumor metastasis or co-existing malignant disease
* Participants previously receiving any prior therapy for HCC, including loco-regional therapies
* Participants who have undergone a liver transplant or those who are in the waiting list for liver transplantation
* Participants who have received a live/attenuated vaccine within 30 days of randomization (eg, varicella, zoster, yellow fever, rotavirus, oral polio and measles, mumps, rubella \[MMR\]).

Other protocol defined inclusion/exclusion criteria apply

Where it's running

• Local Institution - 0081
  Anniston, Alabama, United States
• Mayo Clinic in Arizona - Phoenix
  Phoenix, Arizona, United States
• Arizona Oncology Associates, PC - HOPE
  Tucson, Arizona, United States
• Local Institution - 0135
  Los Angeles, California, United States
• Local Institution - 0088
  Palo Alto, California, United States
• Local Institution - 0085
  San Francisco, California, United States

+134 more sites. See ClinicalTrials.gov for the full list.

Study contacts

• Principal investigator: Bristol-Myers Squibb — Bristol-Myers Squibb

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.