A platform to optimize performance for long-duration space missions

Personalized Performance Optimization Platform (P-POP) for Long Duration Spaceflight

NA · Massachusetts General Hospital · NCT06979570

This study is testing a new system that uses wearable sensors to help astronauts perform better and feel good during long space missions by adjusting their environment based on their needs.

Quick facts

PhaseNA
Study typeInterventional
Enrollment80 (estimated)
Ages18 Years to 64 Years
SexAll
SponsorMassachusetts General Hospital (other)
Locations2 sites (Cambridge, Massachusetts and 1 other locations)
Trial IDNCT06979570 on ClinicalTrials.gov

What this trial studies

This study investigates a personalized, closed-loop platform designed to enhance cognitive and behavioral performance for crews on long-duration space missions. It addresses the challenges posed by high workload, reduced sleep, and limited sensory stimulation, which can affect crew performance and well-being. By utilizing wearable biosensors, the platform adapts the local environment based on real-time feedback to optimize individual performance. The collaboration between Massachusetts General Hospital and the Massachusetts Institute of Technology aims to develop effective countermeasures for maintaining optimal functioning in space.

Who should consider this trial

Good fit: Ideal candidates for this study are healthy adults aged 18 to 64 with normal or corrected-to-normal vision and hearing.

Not a fit: Patients with neurological or psychiatric disorders may not benefit from this study due to the nature of the interventions.

Why it matters

Potential benefit: If successful, this platform could significantly improve cognitive performance and overall well-being for astronauts during long-duration space missions.

How similar studies have performed: While the approach of using closed-loop systems for performance optimization is innovative, similar studies have shown promise in enhancing cognitive function in high-stress environments.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Willingness to participate in the study
* Must be between the ages of 18 to 64
* Normal or corrected-to-normal vision and hearing
* Ability to sit still and stay awake during the experimental sessions

Exclusion Criteria:

* Diagnosis with Neurological or psychiatric disorder
* Participation in a prior study associated with this protocol (due to the learning- curve on some of the behavioral tests)

Where this trial is running

Cambridge, Massachusetts and 1 other locations

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.

View on ClinicalTrials.gov →

Conditions: Sensory Science, Performance Assessment, Countermeasure Evaluation, Neurocognitive Function, Psychological Factors, Long-Duration Spaceflight, Cogntiive Performance, Wearable Biosensors

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.