A new treatment for overcoming fears related to anorexia nervosa

Facing Eating Disorder Fears for Anorexia Nervosa: a Virtual Relapse Prevention Program Targeted At Approach and Avoidance Behaviors

Not applicable Interventional University of Louisville · NCT05596799

This study is testing a new online treatment that helps people with anorexia nervosa face their fears about food and body image to see if it works better than regular treatments.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment70 (estimated)
Ages18 Years to 65 Years
SexAll
SponsorUniversity of Louisville Academic / other
Locations1 site (Louisville, Kentucky)
Trial IDNCT05596799 on ClinicalTrials.gov

What this trial studies

This study evaluates a modular treatment called FED-F that combines exposure therapy with psychoeducation and cognitive skills to help individuals confront their fears surrounding food, weight gain, body perception, and social situations. The research aims to refine and test the acceptability and feasibility of this virtual treatment in a small pilot study, comparing its effectiveness against standard treatment methods. By focusing on core mechanisms that predict relapse in anorexia nervosa, the study seeks to provide a more accessible and effective therapeutic option for patients.

Who should consider this trial

Good fit: Ideal candidates for this study are adults aged 18-65 who have been discharged from intensive treatment for anorexia nervosa or atypical anorexia nervosa within the past six months.

Not a fit: Patients who are under 18, over 65, or have active psychiatric conditions such as high suicidality, mania, or psychosis may not benefit from this study.

Why it matters

Potential benefit: If successful, this treatment could significantly improve recovery outcomes and reduce relapse rates for individuals with anorexia nervosa.

How similar studies have performed: While the specific FED-F approach is novel, similar studies utilizing exposure therapy for eating disorders have shown promising results.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Age 18-65
* Meets criteria for DSM-5 defined AN, AN partial remission, or AN full remission, Atypical Anorexia Nervosa (AAN), AAN partial remission, or AAN full remission
* Has been discharged from intensive (i.e., inpatient, residential, or partial hospital program) in the past 6 months

Exclusion Criteria:

* Under 18
* Over 65
* Does not meet criteria for DSM-5 defined AN, AN partial-remission, or AN full-remission
* High and active Suicidality
* Active Mania
* Active psychosis
* Medically Compromised Status including extremely low weight (less than or equal to 75% median BMI for age, sex, and height)
* Does not meet criteria for DSM-5 defined AN, AN partial remission, or AN full remission, AAN, AAN partial remission, or AAN full remission
* Has not been discharged from intensive (i.e., inpatient, residential, or partial hospital program) in the past 6 months

Where this trial is running

Louisville, Kentucky

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Eating DisordersAnorexia NervosaAnorexia Nervosa in Remissiontherapyeating disorderanorexia nervosatreatmentrelapse prevention
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.