Clinical trial Recruiting at 1 site Interventional Ages 18 and up

A new approach to reduce loneliness in adults

Official title: A Novel Conditioning Approach to Counter Loneliness in Adults

Run by Education University of Hong Kong · NCT06521099 · Data updated 2026-11-12

This study is trying a new 6-session program to see if it can help adults feel less lonely and improve their mood.

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment136 (estimated)
SponsorEducation University of Hong Kong
Academic / other
Locations1 site (Hong Kong)
StatusRecruiting
StartedAugust 19, 2025
Main results expectedDecember 2026
Study endsDecember 2026
Registry record updatedSeptember 10, 2026
Trial IDNCT06521099 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are lonely adults without major psychiatric or neurological disorders.

Probably not a fit

Patients with significant psychiatric disorders or those on medications affecting cognitive functions may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study tests a 6-session conditioning method aimed at reducing loneliness in adults by examining changes in socio-affective processing, depressive symptoms, and neural correlates. Participants will first complete an online loneliness questionnaire, followed by laboratory screening and baseline assessments including mood and functional MRI scans. They will then be randomly assigned to either an evaluative conditioning group or a control group, undergoing a series of sessions designed to alter their emotional responses. After the intervention, participants will be reassessed to evaluate the effectiveness of the conditioning approach on their loneliness and mood.

Why it matters

Potential benefit: If successful, this approach could significantly alleviate feelings of loneliness and improve mental health in affected individuals.

How similar studies have gone: While the approach is novel, similar studies have shown promise in using conditioning techniques to modify emotional responses.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* No histories of learning impairment, major psychiatric disorders or neurological disorders other than depression
* Normal intelligence
* At least primary school education

Exclusion Criteria:

* On medication or treatments within 2 weeks prior to the beginning of the study that would affect the individual's brain, cognitive and affective functions

Where it's running

  • The University of Hong Kong
    Hong Kong, Hong Kong
    Recruiting

Study contacts

  • Principal investigator: Nichol ML Wong, PhD — Education University of Hong Kong
  • Study coordinator: Nichol ML Wong, PhD
  • Email: nmlwong@eduhk.hk
  • Phone: 852-29487431

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.