A cohort of healthy elderly individuals aged 80 and older

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study focuses on individuals aged 80 and older who are generally healthy or have mild age-related medical conditions. It aims to explore the interplay between genetics and health in the elderly population, leveraging advancements from the human genome project to identify genetic variants associated with health phenotypes. Participants will undergo blood or saliva collection to facilitate genetic analysis. The study seeks to enhance understanding of how genetic factors contribute to maintaining health in older adults.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age 80 years or older
2. Eligible for blood draw and/or saliva collection
3. Be reliable, cooperative and willing to comply with all protocol-specified procedures
4. Able to understand and grant informed consent
5. Be healthy or have mild medical conditions that may be associated with the normal aging process, including:

   * Hypertension, well controlled (no more than 3 medications)
   * Osteoporosis, Osteopenia and/or osteoarthritis
   * Benign prostatic hypertrophy
   * Cataracts, Glaucoma, Macular Degeneration
   * Dyslipidemia
   * Hypothyroidism
   * Pre-diabetes/impaired fasting glucose (fasting blood glucose 100-126 mg/dL, if known)

Exclusion Criteria:

1. \< 80 years old
2. Participants have been previously enrolled in The Scripps Genebank Healthy Elderly Cohort
3. Treatment with any investigational agents or devices within thirty days preceding enrollment in the study.
4. Self-reported history or current diagnosis of significant chronic conditions including:

   * Any Cancer (including polycythemia; excluding basal or squamous cell skin cancer).
   * Coronary Artery Disease/Myocardial Infarction
   * Stroke/TIA
   * Deep Vein Thrombosis/Pulmonary Embolus
   * Chronic Renal Disease/Hemodialysis
   * Significant Auto-immune/Inflammatory conditions such as (Rheumatoid Arthritis, Lupus, Crohn's, etc.
   * Alzheimer's/Parkinson's
   * Diabetes (Hemoglobin A1C \> 6.5 % or fasting glucose \>126 mg/dL or treated with oral diabetic medication or insulin if known)
   * Aortic or Cerebral Aneurysm
5. Currently taking any of the following medications on a regular basis:

   * Oral chemotherapeutic agents (ex.: tamoxifen, doxorubicin, mitoxantrone, bleomycin)
   * Anti-platelet agents, not including aspirin (ex.: clopidogrel/plavix, dipyridamole/aggrenox/persantine, ticlopidine/ticlid)
   * Cholinesterase inhibitor for Alzheimer's disease (i.e. donepezil/Aricept)
   * Insulin
6. Subject has a significant medical condition which, in the Investigator's opinion, may interfere with the patient's optimal participation in the study or would potentially confound interpretation of the individual's phenotype.

Where it's running

• Scripps Translational Science Institute
  La Jolla, California, United States Recruiting

Study contacts

• Study coordinator: Sarah Topol, BS
• Email: topol.sarah@scrippshealth.org
• Phone: 858-784-2155

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.