A cohort of healthy elderly individuals aged 80 and older
The Healthy Elderly Longevity Cohort
Scripps Translational Science Institute · NCT01004133
This study looks at healthy older adults aged 80 and up to see how their genes affect their health as they age.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 5000 (estimated) |
| Ages | 80 Years and up |
| Sex | All |
| Sponsor | Scripps Translational Science Institute (other) |
| Drugs / interventions | doxorubicin |
| Locations | 1 site (La Jolla, California) |
| Trial ID | NCT01004133 on ClinicalTrials.gov |
What this trial studies
This observational study focuses on individuals aged 80 and older who are generally healthy or have mild age-related medical conditions. It aims to explore the interplay between genetics and health in the elderly population, leveraging advancements from the human genome project to identify genetic variants associated with health phenotypes. Participants will undergo blood or saliva collection to facilitate genetic analysis. The study seeks to enhance understanding of how genetic factors contribute to maintaining health in older adults.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals aged 80 years or older who are generally healthy or have mild medical conditions associated with aging.
Not a fit: Patients under 80 years old or those with significant chronic conditions may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide insights into the genetic factors that promote healthy aging, potentially leading to improved health strategies for the elderly.
How similar studies have performed: While this study explores a relatively novel approach to understanding health in the elderly, similar studies have shown promise in identifying genetic factors related to aging.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Age 80 years or older 2. Eligible for blood draw and/or saliva collection 3. Be reliable, cooperative and willing to comply with all protocol-specified procedures 4. Able to understand and grant informed consent 5. Be healthy or have mild medical conditions that may be associated with the normal aging process, including: * Hypertension, well controlled (no more than 3 medications) * Osteoporosis, Osteopenia and/or osteoarthritis * Benign prostatic hypertrophy * Cataracts, Glaucoma, Macular Degeneration * Dyslipidemia * Hypothyroidism * Pre-diabetes/impaired fasting glucose (fasting blood glucose 100-126 mg/dL, if known) Exclusion Criteria: 1. \< 80 years old 2. Participants have been previously enrolled in The Scripps Genebank Healthy Elderly Cohort 3. Treatment with any investigational agents or devices within thirty days preceding enrollment in the study. 4. Self-reported history or current diagnosis of significant chronic conditions including: * Any Cancer (including polycythemia; excluding basal or squamous cell skin cancer). * Coronary Artery Disease/Myocardial Infarction * Stroke/TIA * Deep Vein Thrombosis/Pulmonary Embolus * Chronic Renal Disease/Hemodialysis * Significant Auto-immune/Inflammatory conditions such as (Rheumatoid Arthritis, Lupus, Crohn's, etc. * Alzheimer's/Parkinson's * Diabetes (Hemoglobin A1C \> 6.5 % or fasting glucose \>126 mg/dL or treated with oral diabetic medication or insulin if known) * Aortic or Cerebral Aneurysm 5. Currently taking any of the following medications on a regular basis: * Oral chemotherapeutic agents (ex.: tamoxifen, doxorubicin, mitoxantrone, bleomycin) * Anti-platelet agents, not including aspirin (ex.: clopidogrel/plavix, dipyridamole/aggrenox/persantine, ticlopidine/ticlid) * Cholinesterase inhibitor for Alzheimer's disease (i.e. donepezil/Aricept) * Insulin 6. Subject has a significant medical condition which, in the Investigator's opinion, may interfere with the patient's optimal participation in the study or would potentially confound interpretation of the individual's phenotype.
Where this trial is running
La Jolla, California
- Scripps Translational Science Institute — La Jolla, California, United States (RECRUITING)
Study contacts
- Study coordinator: Sarah Topol, BS
- Email: topol.sarah@scrippshealth.org
- Phone: 858-784-2155
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Healthy, Age 80 or older, No chronic disease