Comparing two treatment combinations for relapsed or refractory multiple myeloma

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This Phase 3 clinical trial is a multicenter, randomized, controlled, open-label study that evaluates the efficacy and safety of iberdomide combined with dexamethasone and daratumumab (IberDd) against a standard treatment of daratumumab, bortezomib, and dexamethasone (DVd) in patients with relapsed or refractory multiple myeloma. The study consists of two stages, with approximately 200 patients in stage 1 receiving different doses of iberdomide, followed by an additional 664 patients in stage 2 randomized to one of the two treatment arms. Participants will be treated until disease progression, unacceptable toxicity, or withdrawal of consent, with ongoing follow-up for disease assessment. The study adheres to international guidelines for clinical trials.

Why it matters

Who can join: the full rules

Inclusion Criteria

* Documented diagnosis of multiple myeloma (MM) and measurable disease.
* Received 1 to 2 prior lines of anti-myeloma therapy.
* Must have documented disease progression during or after their last anti-myeloma regimen.
* Eastern Cooperative Oncology Group (ECOG) performance status score of 0, 1 or 2.

Exclusion Criteria

* Any condition that confounds the ability to interpret data from the study.
* Has plasma cell leukemia, Waldenstrom's macroglobulinemia or POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, and skin changes), or clinically significant amyloidosis.
* Known central nervous system involvement with MM.
* Prior therapy with iberdomide.
* Other protocol-defined Inclusion/Exclusion criteria apply.

Where it's running

• The Oncology Institute Of Hope And Innovation
  Cerritos, California, United States Recruiting
• Los Angeles Cancer Network - Fountain Valley
  Fountain Valley, California, United States Recruiting
• USC Norris Comprehensive Cancer Center
  Los Angeles, California, United States Recruiting
• USC Norris Comprehensive Cancer Center
  Newport, California, United States Recruiting
• Yale University School Of Medicine
  New Haven, Connecticut, United States Recruiting
• Ocala Oncology Center
  Ocala, Florida, United States Recruiting

+229 more sites. See ClinicalTrials.gov for the full list.

Study contacts

• Study coordinator: BMS Clinical Trials Contact Center www.BMSClinicalTrials.com
• Email: Clinical.Trials@bms.com
• Phone: 855-907-3286

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Belantamab Mafodotin or Daratumumab with VRd for Newly Diagnosed High-Risk Myeloma

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• Etentamig plus daratumumab versus daratumumab‑lenalidomide‑dexamethasone for newly diagnosed multiple myeloma in patients not eligible for transplant

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• Linvoseltamab versus standard daratumumab‑lenalidomide‑dexamethasone for adults with newly diagnosed, transplant‑ineligible multiple myeloma

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.