810 nm diode laser to lower inflammation and pain after root canal retreatment
Evaluation of the Efficacy of 810 nm Diode Laser Disinfection on Inflammatory Cytokines and Postoperative Pain After Endodontic Retreatment: A Randomized Clinical Trial
This test will see if adding an 810 nm diode laser plus calcium hydroxide during root canal retreatment reduces inflammation and short-term postoperative pain in adults with failed prior root canal therapy and periapical radiolucency.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 52 (estimated) |
| Ages | 20 Years to 40 Years |
| Sex | Male |
| Sponsor | Al-Azhar University Academic / other |
| Locations | 1 site (Cairo) |
| Trial ID | NCT07141459 on ClinicalTrials.gov |
What this trial studies
This interventional protocol applies an 810 nm diode laser disinfection technique alongside standard intracanal calcium hydroxide medication during retreatment of single-rooted teeth with radiographically confirmed periapical radiolucency. The study will collect samples to measure inflammatory cytokine levels and record patients' postoperative pain over a defined follow-up period. Patients must have prior endodontic treatment failure, be asymptomatic at enrollment, and meet radiographic criteria (PAI 3 or 4). Exclusions include recent antibiotics, pregnancy or lactation, systemic disease, non-restorable teeth, root resorption, immature roots, or other anatomic complications.
Who should consider this trial
Good fit: Adults with a single-rooted tooth (root canal form type I) that has failed previous endodontic therapy and shows periapical radiolucency (PAI score 3 or 4), who are asymptomatic, able to consent, and meet exclusion criteria (no recent antibiotics, not pregnant, no systemic disease).
Not a fit: Patients with multi-rooted or non-restorable teeth, active symptoms like swelling or sinus tract, recent antibiotic use, systemic disease, root resorption, immature roots, fractures, or pregnancy/lactation are unlikely to benefit from this protocol.
Why it matters
Potential benefit: If successful, this approach could lower postoperative pain and reduce periapical inflammation, improving the success rate of retreatment and helping preserve natural teeth.
How similar studies have performed: Prior laboratory and clinical work with diode lasers (including 980 nm devices) has shown substantial bacterial reductions in root canals, but published results vary and clinical effects specifically on cytokine changes and postoperative pain are not yet consistently established.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients have single-rooted teeth with root canal form type I. * Have previous endodontic therapy with failure. * Have periapical radiolucency (PAI score of 3 or 4). * Asymptomatic patients who had no pain or swelling had a negative response to palpation and percussion. * Patients who provide written informed consent. Exclusion Criteria: * Patients who had received antibiotic therapy within the past 3 months. Pregnancy and lactation. * Systemic disease. * Physical or mental disability. * Non restorable teeth. * Any signs of resorption, immature roots, fracture, sinus tract and dental anomaly
Where this trial is running
Cairo
- from the outpatient clinic of Endodontic Department, Faculty of Dental Medicine for Girls, Al-Azhar University — Cairo, Egypt (Recruiting)
Study contacts
- Study coordinator: Sabah M. Sobhy, PHD
- Email: sabamorad@yahoo.com
- Phone: 01096529143
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.