810 nm diode laser to improve periapical healing after root canal retreatment
Official title: The Efficiency of 810 nm Diode Laser on Periapical Healing After Root Canal Retreatment Using Cone Beam Computed Tomography: A Randomized Controlled Clinical Trial
Run by Al-Azhar University · NCT07194837 · Data updated 2026-11-12
This trial will test whether using an 810 nm diode laser during root canal retreatment helps periapical lesions heal in patients with failed prior root canal therapy.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 20 Years to 45 Years |
| Sex | All |
| Enrollment | 40 (estimated) |
| Sponsor | Al-Azhar University Academic / other |
| Locations | 1 site (Cairo) |
| Status | Recruiting |
| Started | September 19, 2025 |
| Main results expected | March 1, 2027 |
| Study ends | June 1, 2027 |
| Registry record updated | September 30, 2025 |
| Trial ID | NCT07194837 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults with single-rooted teeth that have failed prior root canal therapy, a periapical radiolucency (PAI score 3 or 4), and who provide written informed consent are eligible.
✕Probably not a fit
Patients who are pregnant or lactating, have recent antibiotic use, systemic disease, non-restorable teeth, root resorption, immature roots, fractures, perforations, or disorders of bone metabolism (or are taking steroids/bisphosphonates) are excluded and unlikely to benefit from this procedure.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Patients with single-rooted teeth and chronic periapical lesions after prior endodontic treatment will undergo root canal retreatment and receive standard disinfection protocols with or without adjunctive 810 nm diode laser application. Calcium hydroxide and sodium hypochlorite will be used as part of conventional retreatment care, and the diode laser group will receive additional laser disinfection. Cone beam CT (CBCT) scans will be obtained to quantify periapical lesion volume and track healing over time. The trial tests the null hypothesis that there is no difference in periapical healing between groups.
Why it matters
Potential benefit: If effective, the diode laser could increase the likelihood of periapical healing after retreatment and reduce the need for periapical surgery.
How similar studies have gone: Previous studies of lasers in endodontics have shown improved bacterial reduction and some short-term benefits, but clinical evidence for long-term periapical healing is mixed and not yet definitive.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients have single rooted teeth with root canal form type I. * Have previous endodontic therapy with failure. * Have periapical radiolucency (PAI score of 3 or 4). * Patients who provide written informed consent. Exclusion Criteria: * Patients who had received antibiotic therapy within the past month. * Pregnancy and lactation. * Systemic disease. * Physical or mental disability. * Non restorable teeth. * Any signs of resorption, immature roots, fracture, perforation. * Bone metabolism disease and/or patients using drugs that affect bone metabolism (such as steroids and bisphosphonates)
Where it's running
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from the outpatient clinic of Endodontic Department, Faculty of Dental Medicine for Girls, Al-Azhar University
Cairo, Egypt Recruiting
Study contacts
- Principal investigator: Sabah M Sobhy, PHD — Al-Azhar University
- Study coordinator: Sabah M. Sobhy, PHD
- Email: sabamorad@yahoo.com
- Phone: +201096529143
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.