8-week lower-limb resistance program for young people with Charcot–Marie–Tooth disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Researchers will enroll two groups of participants aged 15–29 — young people with hereditary sensorimotor polyneuropathy (Charcot–Marie–Tooth) and matched healthy controls — and deliver a supervised progressive lower-limb resistance training program three times per week for eight weeks. Primary outcomes are changes in tibialis anterior muscle thickness and echogenicity measured by ultrasonography; secondary outcomes include muscle architecture (fascicle length, pennation angle), body composition, functional capacity tests, and quality-of-life measures. Outcomes will be compared to baseline within each participant and between the HSPN and control groups to determine relative improvements. The intervention excludes people with contraindicating mobility or medical conditions and those currently engaged in resistance training or using muscle-altering supplements.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Men or women between 15 and 29 years of age with a diagnosis of hereditary sensorimotor polyneuropathy (HSPN) in any of its subtypes, living in the community (for experimental group).
* Healthy men or women between 15 and 29 years of age living in the community (for control group).
* Having active ankle movement within a range from plantarflexion to at least 0° of ankle dorsiflexion, allowing for strength training.

Exclusion Criteria:

* Osteoarticular or mobility impairments that prevent safe performance of resistance exercise training (e.g., ankle arthrodesis).
* Use of nutritional supplements that may affect skeletal muscle regulation (leucine, glutamine, casein, whey protein, fatty acids, creatine, among others).
* Untreated and/or uncontrolled chronic diseases or intellectual disability.
* History of surgery
* Participation in a resistance exercise training program within the past 6 months.

Where it's running

• Temuco, Chile
  Temuco, La Araucanía, Chile Recruiting
• Universidad de La Frontera
  Temuco, La Araucanía, Chile Active not recruiting

Study contacts

• Study coordinator: Fernando J Valenzuela, MSc
• Email: fernando.valenzuela@ufrontera.cl
• Phone: +56950166328

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.