68Ga-FAPI PET combined with cardiac MRI for heart disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is an observational imaging protocol using 68Ga-labeled FAP inhibitor (FAPI) PET performed alongside cardiac magnetic resonance (CMR) to detect myocardial fibrosis in adults with confirmed cardiovascular disease. Participants undergo noninvasive PET/CMR imaging at Shanghai East Hospital without therapeutic intervention, and imaging findings will be correlated with clinical data and standard cardiac assessments. The approach leverages FAP-targeted radiotracers to visualize activated fibroblasts and uses CMR to provide detailed structural and functional information without additional ionizing radiation from the MRI component. The study focuses on adult patients who are clinically stable and able to undergo MRI.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Participants must have a confirmed clinical diagnosis of cardiovascular disease by a cardiologist, based on genetic testing, family history, and comprehensive clinical evaluation including physical examination, echocardiography, and when indicated, cardiac MRI findings.
* Age requirement: \>18 years.
* Patients should demonstrate stable cardiovascular status without significant changes in symptoms, treatment, or clinical findings for a specified pre-enrollment period.
* Participants must be capable of providing informed consent and willing to adhere to all study requirements, including follow-up procedures.

Exclusion Criteria:

* History of malignancy
* Documented cardiovascular diseases, including coronary artery disease, myocardial infarction, or related conditions
* Implanted metallic devices (e.g., pacemakers, aneurysm clips) or other MRI-incompatible medical prostheses
* Claustrophobia
* Pregnancy or lactation
* Known hypersensitivity to gadolinium-based contrast agents
* Renal impairment (eGFR \<30 mL/min/1.73m² by CKD-EPI equation)

Where it's running

• Shanghai East Hospital
  Shanghai, Shanghai Municipality, China Recruiting

Study contacts

• Study coordinator: Jie Ding, MD
• Email: dingjie940406@163.com
• Phone: 086-38804518

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.