3D versus 2D surveillance colonoscopy for finding adenomas
Comparison of the Performance Between Conventional Colonoscopy and 3D Colonoscopy in Surveillance Colonoscopy: A Multi-center, Randomized Controlled Trial
This trial tests whether 3D colonoscopy finds more adenomas than standard 2D colonoscopy in adults aged 40 and older who need surveillance colonoscopy after prior polypectomy.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 500 (estimated) |
| Ages | 40 Years and up |
| Sex | All |
| Sponsor | National Taiwan University Hospital Academic / other |
| Locations | 3 sites (Hsinchu, Taiwan and 2 other locations) |
| Trial ID | NCT07076966 on ClinicalTrials.gov |
What this trial studies
Adults aged 40 and older requiring surveillance colonoscopy after a prior polypectomy are enrolled and undergo colonoscopy with either a 3D imaging device or standard 2D imaging. Endoscopists remove detected polyps per routine care and the study compares adenoma detection rate (ADR), including detection of non-polypoid (flat or depressed) lesions, between the two imaging approaches. Key exclusions include hereditary polyposis, prior colectomy, inflammatory bowel disease, inadequate bowel preparation, or any contraindication to colonoscopy. The trial is being conducted at multiple National Taiwan University Hospital sites in Taipei and Hsinchu.
Who should consider this trial
Good fit: Ideal candidates are adults aged 40 or older who need surveillance colonoscopy more than one year after prior polypectomy and who do not have hereditary polyposis, prior colectomy, inflammatory bowel disease, or contraindications to colonoscopy.
Not a fit: Patients with contraindications to colonoscopy, hereditary polyposis, prior colectomy, inflammatory bowel disease, or inadequate bowel preparation are unlikely to benefit or be eligible for this comparison.
Why it matters
Potential benefit: If successful, 3D colonoscopy could increase detection of adenomas—especially flat lesions—and reduce patients' future risk of colorectal cancer.
How similar studies have performed: Previous prospective work, including a trial by this team, has shown that 3D colonoscopy can significantly improve overall ADR and detection of non-polypoid adenomas, providing supporting evidence for this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Subjects who are 40 years of older * Subjects who receive colonoscopy and polypectomy more the 1 year * Subjects who need surveillance colonoscopy Exclusion Criteria: * Contraindication for colonoscopy * Subjects with familiar or hereditary polyposis * Subjects with history of colectomy * Inadequate bowel cleansing level * Subjects with inflammatory bowel disease
Where this trial is running
Hsinchu, Taiwan and 2 other locations
- National Taiwan University Hospital, Hsinchu Branch — Hsinchu, Taiwan, Taiwan (Recruiting)
- National Taiwan University Cancer Center — Taipei, Taiwan, Taiwan (Recruiting)
- National Taiwan University Hospital — Taipei, Taiwan, Taiwan (Recruiting)
Study contacts
- Study coordinator: Li-Chun Chang, MD. PhD.
- Email: lichunchang@ntu.edu.tw
- Phone: 886-9-72-651-258
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.