3D versus 2D surveillance colonoscopy for finding adenomas
Official title: Comparison of the Performance Between Conventional Colonoscopy and 3D Colonoscopy in Surveillance Colonoscopy: A Multi-center, Randomized Controlled Trial
Run by National Taiwan University Hospital · NCT07076966 · Data updated 2026-11-12
This trial tests whether 3D colonoscopy finds more adenomas than standard 2D colonoscopy in adults aged 40 and older who need surveillance colonoscopy after prior polypectomy.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 40 Years and up |
| Sex | All |
| Enrollment | 660 (estimated) |
| Sponsor | National Taiwan University Hospital Academic / other |
| Locations | 3 sites (Hsinchu and 2 other locations) |
| Status | Recruiting |
| Started | January 1, 2024 |
| Main results expected | December 31, 2026 |
| Study ends | February 28, 2027 |
| Registry record updated | September 29, 2026 |
| Trial ID | NCT07076966 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 40 or older who need surveillance colonoscopy more than one year after prior polypectomy and who do not have hereditary polyposis, prior colectomy, inflammatory bowel disease, or contraindications to colonoscopy.
✕Probably not a fit
Patients with contraindications to colonoscopy, hereditary polyposis, prior colectomy, inflammatory bowel disease, or inadequate bowel preparation are unlikely to benefit or be eligible for this comparison.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Adults aged 40 and older requiring surveillance colonoscopy after a prior polypectomy are enrolled and undergo colonoscopy with either a 3D imaging device or standard 2D imaging. Endoscopists remove detected polyps per routine care and the study compares adenoma detection rate (ADR), including detection of non-polypoid (flat or depressed) lesions, between the two imaging approaches. Key exclusions include hereditary polyposis, prior colectomy, inflammatory bowel disease, inadequate bowel preparation, or any contraindication to colonoscopy. The trial is being conducted at multiple National Taiwan University Hospital sites in Taipei and Hsinchu.
Why it matters
Potential benefit: If successful, 3D colonoscopy could increase detection of adenomas—especially flat lesions—and reduce patients' future risk of colorectal cancer.
How similar studies have gone: Previous prospective work, including a trial by this team, has shown that 3D colonoscopy can significantly improve overall ADR and detection of non-polypoid adenomas, providing supporting evidence for this approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Subjects who are 40 years of older * Subjects who receive colonoscopy and polypectomy more the 1 year * Subjects who need surveillance colonoscopy Exclusion Criteria: * Contraindication for colonoscopy * Subjects with familiar or hereditary polyposis * Subjects with history of colectomy * Inadequate bowel cleansing level * Subjects with inflammatory bowel disease
Where it's running
-
National Taiwan University Hospital, Hsinchu Branch
Hsinchu, Taiwan Recruiting -
National Taiwan University Cancer Center
Taipei, Taiwan Recruiting -
National Taiwan University Hospital
Taipei, Taiwan Recruiting
Study contacts
- Study coordinator: Li-Chun Chang, MD. PhD.
- Email: lichunchang@ntu.edu.tw
- Phone: 886-9-72-651-258
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.