Clinical trial Recruiting at 1 site Interventional Ages 40 to 55 Women only

3D ultrasound versus hysteroscopy for perimenopausal bleeding

Official title: Three Dimensional Ultrasonography Versus Hysteroscopy for the Evaluation of Patients With Perimenopausal Bleeding

Run by Sohag University · NCT07309692 · Data updated 2026-11-12

This compares 3D ultrasound and hysteroscopy to see which better finds the cause of abnormal uterine bleeding in women aged 40–55 during the perimenopausal period.

Quick facts

Study typeInterventional
Ages40 Years to 55 Years
SexWomen only
Enrollment106 (estimated)
SponsorSohag University
Academic / other
Locations1 site (Sohag)
StatusRecruiting
StartedDecember 1, 2025
Main results expectedAugust 31, 2026
Study endsAugust 31, 2026
Registry record updatedDecember 30, 2025
Trial IDNCT07309692 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Women aged 40–55 with abnormal uterine bleeding (menorrhagia or metrorrhagia) lasting more than three months, without ovarian lesions or local vaginal/cervical causes, and not using hormonal therapy or an IUD.

Probably not a fit

Women who are postmenopausal, pregnant, have systemic conditions causing bleeding (such as diabetes, hypertension, or chronic liver disease), are on hormonal therapy or using an IUD, or have contraindications to hysteroscopy (for example cervical stenosis) are excluded and unlikely to benefit from this comparison.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Women aged 40–55 with at least three months of abnormal uterine bleeding will undergo evaluation using three-dimensional transvaginal ultrasonography and hysteroscopy. Investigators will compare the imaging and procedural findings to determine how well 3D ultrasound detects intrauterine causes of bleeding relative to hysteroscopy. The protocol excludes postmenopausal women, those with systemic causes of bleeding, current hormonal therapy or intrauterine devices, pregnancy, or contraindications to hysteroscopy. The study is conducted at Sohag University and uses the two modalities to directly compare diagnostic findings in the same clinical population.

Why it matters

Potential benefit: If successful, this could allow more cases to be diagnosed using a less invasive and quicker 3D ultrasound exam, reducing the need for invasive hysteroscopy in some patients.

How similar studies have gone: Previous work shows transvaginal and 3D ultrasound can detect many intrauterine abnormalities, but hysteroscopy remains the diagnostic reference standard.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

Any pattern of abnormal uterine bleeding as menorrhagia or metrorrhagia for more than 3 months at age between 40 and 55 years , and no ovarian lesion or local cause of bleeding as vaginal or cervical ulcer

Exclusion Criteria:

* • Women with postmenopausal bleeding.

  * Systemic causes of perimenopausal bleeding DM Hypertension or chronic liver disease.
  * Women on hormonal therapy or using any contraception as IUD.
  * Women have contraindication for hysteroscopy as cervical stenosis or pregnancy.

Where it's running

  • Sohag University
    Sohag, Egypt
    Recruiting

Study contacts

Similar studies

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
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Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.