3D-printed hybrid resin versus CAD/CAM composite overlays for endodontically treated molars
Clinical Behavior of 3D-Printed VarseoSmile TriniQ Resin Versus CAD/CAM Cerasmart in Indirect Restorations for Endodontically Treated Teeth: A Randomized Clinical Trial
This will test whether 3D-printed hybrid resin restorations or milled CAD/CAM composite restorations—using one of two cementation methods—work better for restoring endodontically treated molars.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 60 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Universitat Internacional de Catalunya Academic / other |
| Locations | 1 site (Sant Cugat del Vallès, Barcelona) |
| Trial ID | NCT07465978 on ClinicalTrials.gov |
What this trial studies
This randomized trial at the University Dental Clinic of the Universitat Internacional de Catalunya will enroll 60 patients needing an indirect adhesive overlay on an endodontically treated molar. Participants are randomly assigned to receive restorations made either from a 3D-printed hybrid resin (VarseoSmile TriniQ) or a CAD/CAM composite block (Cerasmart), with each material group further randomized to cementation with either a preheated microhybrid composite (Enamel Plus HRi) or a resin cement (RelyX Universal). All restorations are produced using a digital workflow including intraoral scanning, CAD design, and either additive (3D printing) or subtractive (milling) manufacturing, followed by adhesive cementation per the assigned protocol. Clinical performance and any complications will be recorded at follow-up visits to compare materials and luting protocols.
Who should consider this trial
Good fit: Adults (≥18) with an endodontically treated molar needing a full-cuspal indirect adhesive overlay who have no active periodontal disease, no high caries risk, and a natural antagonist tooth.
Not a fit: Patients with uncontrolled parafunctional habits (e.g., bruxism), poor oral hygiene, active pulpal or periodontal disease, insufficient interarch space, or teeth intended as prosthesis abutments are unlikely to benefit or be eligible.
Why it matters
Potential benefit: If successful, this could identify a durable, clinically acceptable option for restoring root-canal treated molars and clarify the better cementation method.
How similar studies have performed: Composite CAD/CAM blocks like Cerasmart have shown good clinical performance in prior studies, while clinical evidence for definitive 3D-printed hybrid resins is still limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥18 years * Signed informed consent * Need to restore an endodontically treated molar with an indirect adhesive overlay * Physically and psychologically able to tolerate conventional restorative procedures * No high caries risk * No active periodontal disease * Natural antagonist tooth present * Need for full cuspal coverage restoration (overlay) * Remaining wall thickness \<3 mm in the endodontically treated tooth * Occlusal thickness of the restoration ≥1 mm * Willing and able to attend follow-up visits Exclusion Criteria: * Poor oral hygiene * Uncontrolled parafunctional habits (e.g., bruxism) * High caries risk * Active periodontal disease * Active pulpal disease * Absence of natural antagonist tooth * Need for partial cuspal coverage restoration (inlay or onlay) * Insufficient interarch space for restoration * Teeth planned as abutments for removable or fixed prostheses * Known allergy to any materials used in the study
Where this trial is running
Sant Cugat del Vallès, Barcelona
- Clínica Universitària d'Odontologia UIC Barcelona — Sant Cugat del Vallès, Barcelona, Spain (Recruiting)
Study contacts
- Principal investigator: Marta Valles — Universitat Internacional de Catalunya
- Study coordinator: MARTA VALLES, DDS, PhD
- Email: mvalles@uic.es
- Phone: +34619747903
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.