3D imaging technique for diagnosing knee osteoarthritis
Development of Spin-lock and FSE Acquisitions Based 3D Quantitative Biochemical Imaging for Osteoarthritis
This study is testing a new 3D imaging method to see if it can help doctors diagnose and monitor knee osteoarthritis better in adults who have been living with knee pain.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 50 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Chinese University of Hong Kong Academic / other |
| Locations | 1 site (Hong Kong) |
| Trial ID | NCT04431752 on ClinicalTrials.gov |
What this trial studies
This observational study focuses on developing a novel 3D quantitative biochemical imaging technique using spin-lock and fast spin echo (FSE) acquisitions to improve the diagnosis and monitoring of knee osteoarthritis (OA). The study aims to address the rising prevalence of OA, particularly among the elderly population in Hong Kong, by utilizing advanced magnetic resonance imaging (MRI) technology. Participants will include adults over 18 years old who have been diagnosed with primary knee OA and have experienced pain for at least two months. The study seeks to enhance early diagnosis and treatment monitoring for OA, which is crucial given the socio-economic burden of the disease.
Who should consider this trial
Good fit: Ideal candidates for this study are adults over 18 years old who have been diagnosed with primary knee osteoarthritis and have experienced pain symptoms for at least two months.
Not a fit: Patients with contraindications to MRI, inflammatory arthritis, or severe comorbid conditions may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved early diagnosis and monitoring of knee osteoarthritis, potentially reducing disability and enhancing quality of life for patients.
How similar studies have performed: While this approach is innovative, similar imaging techniques have shown promise in other studies, suggesting potential for success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * All Patients over the age of 18 * All patients must provide their written consent In the OA group * Patients must be affected by primary osteoarthritis of the knee (according to ACR - American College of Rheumatology - classification) * All patients must have pain symptoms for more than or equal to 2 months * Radiological evidence of osteoarthritis Exclusion Criteria: * Contraindication to MRI * Patient with a mental disability * Claustrophobia * Inflammatory arthritis * Ongoing Pregnancy and breast-feeding * Presence of severe diseases like terminal cancers * Presence of metalwork in the knee * Significant hematological diseases; * Non-consenting patients who have not provided the written Informed Consent * Gross lower limb deformity
Where this trial is running
Hong Kong
- Department of Orthopaedics & Traumatology — Hong Kong, Hong Kong (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.