24-hour clear liquid diet before anesthesia for people taking GLP-1 receptor agonists
Official title: Protective Benefits of a Clear Liquid Diet on Residual Gastric Content in Patients Taking Glucagon Like Peptide-1 Receptor Agonist Prior to Anesthesia
Run by The University of Texas Health Science Center, Houston · NCT06654219 · Data updated 2026-11-12
This trial will test whether switching to a clear liquid diet for 24 hours before upper endoscopy reduces leftover stomach contents in people taking GLP-1 receptor agonist medications.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 136 (estimated) |
| Sponsor | The University of Texas Health Science Center, Houston Academic / other |
| Locations | 1 site (Houston, Texas) |
| Status | Recruiting |
| Started | October 30, 2025 |
| Main results expected | December 31, 2026 |
| Study ends | December 31, 2026 |
| Registry record updated | August 4, 2026 |
| Trial ID | NCT06654219 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults taking GLP-1 receptor agonists who are scheduled for upper endoscopy and can tolerate ultrasound and positional changes are ideal candidates.
✕Probably not a fit
Patients with prior gastric surgery or bypass, gastric band, fundoplication, large hiatal hernia, known gastroparesis, pregnancy, recent trauma, or those taking excluded prokinetic or opioid medications were excluded and are unlikely to benefit from these fasting instructions.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This interventional study enrolls patients taking GLP-1 receptor agonists who are scheduled for upper endoscopy and randomizes them to prolonged fasting from solids with a 24-hour clear liquid diet versus standard NPO instructions. Residual gastric content will be measured by preoperative gastric ultrasound and by direct visualization during endoscopy, with serial ultrasound scans every two hours for subjects with initially at-risk scans. The study also tracks patient symptoms (thirst, hunger, anxiety, nausea, vomiting, bloating, and pain), anesthesia choices, adverse events, and whether duration of GLP-1 RA therapy relates to gastric contents. The trial is conducted at the University of Texas Health Science Center at Houston.
Why it matters
Potential benefit: If successful, this approach could reduce the amount of residual stomach contents and lower aspiration risk for patients on GLP-1 receptor agonists undergoing anesthesia.
How similar studies have gone: Prior evidence indicates GLP-1 receptor agonists can slow gastric emptying, but randomized comparisons of prolonged clear liquid diets before anesthesia in this population are limited, so the approach is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients taking Glucagon Like Peptide-1 Receptor (GLP-1 RA) agonists * Undergoing upper endoscopy only - no colonoscopy due to prep Exclusion Criteria: * Previous gastric resection or bypass * Gastric band in situ * Previous fundoplication * Large hiatal hernia * Pregnant patients * Recent trauma * Inability to turn to the right lateral decubitus position. * Patients on erythromycin, metoclopramide, domperidone, opioids. * Gastroparesis previous
Where it's running
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The University of Texas Health Science Center at Houston
Houston, Texas, United States Recruiting
Study contacts
- Principal investigator: Sudipta Sen, MD, FASA — The University of Texas Health Science Center, Houston
- Study coordinator: Sudipta Sen, MD, FASA
- Email: Sudipta.Sen@uth.tmc.edu
- Phone: (713) 500-6202
Similar studies
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.