20 g beetroot powder to help lower blood pressure in men with hypertension
Official title: The Influence of Beetroot Powder at a Dose of 20 g on Blood Pressure, Microcirculation, and Biochemical Markers in Men With Arterial Hypertension.SVEKLA2025.
Run by National Medical Research Center for Therapy and Preventive Medicine · NCT07270718 · Data updated 2026-11-12
This trial will test whether taking a 20 g dose of dried beetroot powder (about 800 mg nitrate) helps men with treated high blood pressure keep their blood pressure at target levels.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 60 Years |
| Sex | Men only |
| Enrollment | 60 (estimated) |
| Sponsor | National Medical Research Center for Therapy and Preventive Medicine Government |
| Locations | 1 site (Moscow) |
| Status | Recruiting |
| Started | January 24, 2025 |
| Main results expected | August 2026 |
| Study ends | December 2026 |
| Registry record updated | December 8, 2025 |
| Trial ID | NCT07270718 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Men with hypertensive heart disease who are on regular antihypertensive treatment and have reached target blood pressure by home/ambulatory monitoring, and who do not meet exclusion criteria such as heart disease, diabetes, or BMI ≥30 kg/m2, are the ideal candidates.
✕Probably not a fit
Patients with coronary artery disease, prior stroke, heart failure symptoms, diabetes, obesity (BMI ≥30), or other listed exclusions are unlikely to benefit and are excluded from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a randomized, open-label trial enrolling men with hypertensive heart disease who have reached target blood pressure on stable antihypertensive therapy. Participants receive a single food intervention of 20 g finely dispersed beetroot powder (≈800 mg nitrate) and are monitored for effects on office and ambulatory blood pressure, microcirculation measures, and biochemical markers related to nitric oxide bioavailability. The rationale is that dietary nitrate is converted to nitric oxide in the body and may improve endothelial vasodilation and lower blood pressure. Outcomes will compare blood pressure regulation, microcirculatory function, and biomarkers between groups to determine short-term physiological effects of the beetroot preparation.
Why it matters
Potential benefit: If effective, a simple dietary supplement could help lower or better stabilize blood pressure and improve blood-vessel function in men already on antihypertensive therapy.
How similar studies have gone: Prior clinical studies of dietary nitrate and beetroot products have shown modest reductions in blood pressure and some improvements in endothelial function in selected populations, supporting but not definitively proving this approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * A history of hypertension with achievement of the target blood pressure level according to the SMAD while taking regular AGT; * signing informed consent to participate in the study. Exclusion Criteria: * coronary heart disease, including angina pectoris and myocardial infarction; cerebrovascular disease, including acute cerebrovascular accident and transient ischemic attack; obliterating atherosclerosis of peripheral vessels, revascularization in any vascular basin; cardiomyopathy; secondary forms of hypertension; type 1 or 2 diabetes mellitus, impaired glucose tolerance; inflammatory bowel diseases; organ transplantation; oncological, mental illnesses; diffuse connective tissue diseases in the anamnesis; * BMI ≥30 kg/m2; * symptoms of heart failure; * acute infectious diseases at the time of inclusion in the study and within 1 month prior to inclusion in the study; * Exacerbation of chronic non-communicable diseases; * alcoholism, taking narcotic drugs; * allergic and undesirable reactions to foods containing beetroot and egg white in the anamnesis; * refusal to continue participating in the study
Where it's running
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National Medical Research Center for Preventive Medicine
Moscow, Russia Recruiting
Study contacts
- Study coordinator: Andrey I. Korolev, PhD
- Email: dr.korolev.andrei@gmail.com
- Phone: +7 963-611-9912
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.