177Lu-PSMA-617 treatment for advanced prostate cancer in Japan

A Prospective, Open Label, Multicenter, Single Arm, Phase 2 Study of 177Lu-PSMA-617 in the Treatment of Participants With Progressive PSMA- Positive Metastatic Castration-resistant Prostate Cancer (mCRPC) in Japan

This study is testing a new treatment called 177Lu-PSMA-617 for men with advanced prostate cancer to see if it helps them when other treatments have failed or if they haven't had those treatments yet.

Quick facts

• Phase: Phase 2
• Study type: Interventional
• Enrollment: 110 (estimated)
• Ages: 20 Years to 100 Years
• Sex: Male
• Sponsor: Novartis (Industry-sponsored)
• Drugs / interventions: chemotherapy, immunotherapy, methotrexate
• Locations: 8 sites (Kashiwa, Chiba and 7 other locations)
• Trial ID: NCT05114746 on ClinicalTrials.gov

What this trial studies

This study evaluates the efficacy, safety, and pharmacokinetics of 177Lu-PSMA-617 in men with metastatic castration-resistant prostate cancer (mCRPC) who are positive for prostate-specific membrane antigen (PSMA). It includes two populations: those who have previously undergone taxane chemotherapy and those who have not. The study is designed as an open-label, multicenter, single-arm phase II trial, and also assesses the safety and pharmacokinetics of the imaging agent 68Ga-PSMA-11. The trial aims to provide access to these treatments for eligible patients until they are commercially available in Japan.

Who should consider this trial

Good fit: Ideal candidates are men with PSMA-positive mCRPC who have either undergone prior taxane treatment or are suitable for delaying taxane-based chemotherapy.

Not a fit: Patients who have not been diagnosed with PSMA-positive mCRPC or those who have not received prior treatment with ARDT may not benefit from this study.

Why it matters

Potential benefit: If successful, this treatment could provide a new therapeutic option for patients with advanced prostate cancer, potentially improving outcomes and quality of life.

How similar studies have performed: Other studies using PSMA-targeted therapies have shown promising results, indicating that this approach may be effective for treating advanced prostate cancer.

Eligibility criteria

Key Inclusion Criteria:

* ECOG performance status:

  1. Post-taxane population only: 0 to 2.
  2. Pre-taxane population only: 0 to 1.
* Participants must have a previous histological, pathological, and/or cytological confirmation of prostate cancer.
* Part 1/2/3 only; Participants must have a positive 68Ga-PSMA-11 PET/CT scan, as determined by the sponsor's central reader, before the enrollment to 177Lu-PSMA-617 treatment period.
* Participants must have a positive 68Ga-PSMA-11 PET/CT scan, as determined by the local investigator, before the enrollment to 177Lu-PSMA-617 treatment period.
* Participants must have a castrate level of serum/plasma testosterone (\<50 ng/dL or \<1.7 nmol/L).
* Post-taxane population only: Participants must have received at least one ARDT (for example enzalutamide, abiraterone, apalutamide, or darolutamide, etc.) in either the hormone-sensitive/castrate-resistant or non-metastatic/metastatic prostate cancer setting.
* Pre-taxane population only: Participants must have progressed only once on prior second generation ARDT (abiraterone, enzalutamide, darolutamide, or apalutamide) and be a candidate for change in ARDT as assessed by the treating physician.

  1. first generation androgen receptor inhibitor therapy (e.g. bicalutamide) is allowed but not considered as prior ARDT therapy
  2. second generation ARDT must be the most recent therapy received.
* Post-taxane population only: Participants must have been previously treated with at least 1, but no more than 2 prior taxane regimens. A taxane regimen is defined as a minimum exposure of 2 cycles of a taxane. If a participant has received only 1 taxane regimen, the participant is eligible if :

  a. The participant's physician deems him unsuitable to receive a second taxane regimen (e.g., frailty assessed by geriatric or health status evaluation or intolerance, etc.).
* Participants must have progressive mCRPC. Documented progressive mCRPC will be based on at least 1 of the following criteria:

  1. Serum PSA progression defined as 2 consecutive increases in PSA over a previous reference value measured at least 1 week prior. 1.0 ng/mL is the minimal starting value if confirmed rise in PSA is the only indication of progression.
  2. Soft-tissue progression defined as an increase \>= 20% in the sum of the diameter (SOD) (short axis for nodal lesions and long axis for non-nodal lesions) of all target lesions based on the smallest SOD since treatment started or the appearance of one or more new lesions.
  3. Progression of bone disease: two new lesions; only positivity on the bone scan defines metastatic disease to bone (PCWG3 criteria, Scher et al 2016).
* Part 1/2/3 only; Participants must have at least one measurable lesion per PCWG3-modified RECIST v1.1 on CT or MRI.

Key Exclusion Criteria:

* Previous treatment with any of the following within 6 months of the enrollment: Strontium-89, Samarium-153, Rhenium-186, Rhenium-188, Radium-223, hemi-body irradiation. Previous PSMA-targeted therapy is not allowed.
* Post-taxane population: Any systemic anti-cancer therapy (e.g. chemotherapy, immunotherapy or biological therapy \[including monoclonal antibodies\], ARDT is not included) within 28 days prior to day of the enrollment.
* Pre-taxane population: Prior treatment with PARP inhibitor, cytotoxic chemotherapy for castration resistant or castrate sensitive prostate cancer (e.g., taxanes, platinum, estramustine, vincristine, methotrexate, etc.), immunotherapy or biological therapy \[including monoclonal antibodies\]) \[Note: Taxane exposure (maximum 6 cycles) in the adjuvant or neoadjuvant setting is allowed if 12 months have elapsed since completion of this adjuvant or neoadjuvant therapy\]
* Known hypersensitivity to the components of 177Lu-PSMA-617, 68Ga-PSMA-11 or excipients or to drugs of similar classes.
* Concurrent cytotoxic chemotherapy, immunotherapy, radioligand therapy, PARP inhibitors, biological, AKT inhibitors or investigational therapy.
* Participants with a history of CNS metastases must have received therapy (surgery, radiotherapy, gamma knife) and be neurologically stable, asymptomatic, and not receiving corticosteroids for the purposes of maintaining neurologic integrity.
* Symptomatic cord compression, or clinical or radiologic findings indicative of impending cord compression.

Where this trial is running

Kashiwa, Chiba and 7 other locations

• Novartis Investigative Site — Kashiwa, Chiba, Japan (Recruiting)
• Novartis Investigative Site — Fukushima city, Fukushima, Japan (Recruiting)
• Novartis Investigative Site — Sapporo city, Hokkaido, Japan (Recruiting)
• Novartis Investigative Site — Kobe, Hyogo, Japan (Recruiting)
• Novartis Investigative Site — Kanazawa, Ishikawa, Japan (Recruiting)
• Novartis Investigative Site — Yokohama-city, Kanagawa, Japan (Recruiting)
• Novartis Investigative Site — Chiba, Japan (Recruiting)
• Novartis Investigative Site — Kyoto, Japan (Recruiting)

Study contacts

• Study coordinator: Novartis Pharmaceuticals

Conditions Prostate Cancer; 177Lu-PSMA-617; 68Ga-PSMA-11; 68Ge/68Ga Generator; metastatic castration-resistant prostate cancer; mCRPC; prostate-specific membrane antigen; PSMA