16F vs 24F chest drain after minimally invasive lobectomy or segmentectomy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults undergoing minimally invasive anatomical lung resection (lobectomy or segmentectomy) will receive either a 16F or a 24F chest tube, with predefined protocols for early or standard removal. Postoperative pain scores, respiratory function, and drain-related complications such as air leak and pleural effusion will be recorded and compared between groups. The study is conducted at University Hospital Basel and enrolls patients who meet operative and medical eligibility criteria. The goal is to determine whether a smaller-bore drain reduces pain without increasing postoperative complications.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Informed Consent signed by the patient (all sex and gender)
* Patients' age from ≥ 18 to no age limit at time of study inclusion
* American Society of Anaesthesiologists (ASA) physical status classification I to IV
* Patients with resectable non-small cell lung cancer (NSCLC) deemed operable by minimally invasive surgical technique.
* Minimally invasive anatomical lung resections under general anaesthesia: lobectomy, lobectomy with wedge resection, lobectomy combined with segmentectomy, segmentectomy with wedge resection, bilobectomy

Exclusion Criteria:

* Previous thoracic surgery on the same side within 3 months
* Lung cancer complicated with pleural empyema
* Patients with chronic pain who receive opioids/gabapentin/pregabalin
* Patients who consume opiates/benzodiazepines
* Congestive heart failure NYHA Class III or IV
* Liver cirrhosis Child-Pugh Class B and C
* Renal insufficiency requiring dialysis and/or estimated glomerular filtration rate (eGFR) \<30 mL/min/1.73 m2
* Patients with coagulopathy or bleeding disorders: von Willebrand disease, Hemophilia; Thrombocytopenia (\<50 G/l), requiring platelet transfusion
* Patients with neuralgia
* Chest pain (site of surgery) without taking painkillers, measured by VAS while coughing \> 10 mm
* Not consolidated rib fractures (in the last 3 months) on the side of surgical procedure
* Open anatomical lung resection, including pneumonectomy
* Insertion of 2 or more chest tubes
* Need for patient controlled intravenous anaesthesia or patient controlled epidural anaesthesia
* Patients intubated/sedated (not suitable due to difficulties to fill out the pain survey)

Where it's running

• University Hospital Basel
  Basel, Switzerland Recruiting

Study contacts

• Principal investigator: Makhmudbek Mallaev, MD — University Hospital, Basel, Switzerland
• Study coordinator: Helga Bachmann, MSc Clinical Research
• Email: helga.bachmann@usb.ch
• Phone: +41 (0)61 328 71 70

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.