12-week exercise program for people with hereditary transthyretin (ATTRv) amyloidosis
Official title: Effects of a 12-week Exercise Intervention on Physical and Mental Health in Hereditary ATTR (ATTRv) Amyloidosis
Run by University of Maia · NCT07033715 · Data updated 2026-11-12
This 12-week exercise program will try to see if regular physical activity improves fitness and mental well-being for people with hereditary ATTR (ATTRv) amyloidosis in early stages.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 42 (estimated) |
| Sponsor | University of Maia Academic / other |
| Locations | 1 site (Maia, Porto District) |
| Status | Recruiting |
| Started | October 1, 2024 |
| Main results expected | September 30, 2025 |
| Study ends | September 30, 2026 |
| Registry record updated | June 24, 2025 |
| Trial ID | NCT07033715 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults with genetically confirmed hereditary ATTR (ATTRv) amyloidosis in disease stage 1 or 2 who live in Portugal, have no medical contraindication to exercise, and can give informed consent are ideal candidates.
✕Probably not a fit
People with advanced disease beyond stage 2, those with a medical contraindication to exercise, or those who had a liver transplant within the past six months are unlikely to benefit from this program.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This interventional study delivers a supervised 12-week exercise program to people with hereditary transthyretin-related amyloidosis (ATTRv) who are in disease stage 1 or 2. Participants will be recruited in Portugal and will undergo baseline and post-intervention measures of physical fitness, mental health, and health-related quality of life while continuing their current medical therapies. The protocol explicitly includes patients receiving newer ATTR therapies and expands outcomes beyond physical performance to capture psychological and HRQoL effects. By comparing outcomes before and after the intervention, researchers aim to add evidence on the safety and potential benefits of exercise in this under-studied population.
Why it matters
Potential benefit: If successful, the program could improve physical fitness, reduce mental burden, and enhance overall health-related quality of life for people with early-stage ATTRv.
How similar studies have gone: Only a few prior studies—mainly in liver-transplanted patients—have reported physical fitness benefits, while mental health effects in non-transplanted ATTRv patients remain largely untested.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * ATTRv Amyloidosis patients living in Portugal; * Disease stage 1 or 2; * No medical contraindication for exercising; * Ability to provide informed consent. Exclusion Criteria: \- Having undergone a liver transplant in the past 6 months.
Where it's running
-
University of Maia
Maia, Porto District, Portugal Recruiting
Study contacts
- Study coordinator: Cláudia F. Barata, PhD
- Email: claudiapfb19@gmail.com
- Phone: +351915381161
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.