Study summary

YL201 shrank tumors across several cancers

YL201 early trial · 287 people, including 37 with squamous esophageal cancer · Published 2025, Nature Medicine

41%of tumors shrank, all cancers combined

What was tested

YL201, an antibody-drug conjugate aimed at B7-H3, in people with advanced solid tumors after other treatments. No comparison group.

What they found

What it means

Enough to start a 440-person phase 3 in this cancer, finishing around April 2028.

CancerNetwork ↗ ← Back to the outlook
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.