Study summary

An EZH1/2 inhibitor shrank tumors in 44% of people with relapsed disease

VALENTINE-PTCL01 trial · 133 people, phase 2 · Published October 2024, Lancet Oncology

44%response rate

What was tested

Valemetostat, a pill that blocks the EZH1 and EZH2 enzymes controlling gene activity in lymphoma cells, for relapsed or refractory peripheral T-cell lymphoma.

What they found

What it means

Approved in Japan; one of several epigenetic drugs that work well in T-cell lymphomas.

Lancet Oncol, via PubMed ↗ ← Back to the outlook
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