Study summary
A bedtime tablet eased fibromyalgia pain more than placebo
1.8 vs 1.2points of pain relief on a 0 to 10 scale, Tonmya vs placebo
What was tested
Tonmya, a low-dose form of cyclobenzaprine that dissolves under the tongue at bedtime, against placebo for 14 weeks.
What they found
- Average daily pain fell by 1.8 points with Tonmya and 1.2 with placebo.
- About 7 people need to take it for one extra person to get at least 30% pain relief.
- Sleep, fatigue and overall symptom scores also improved.
- 6.1% stopped because of side effects, against 3.5% on placebo.
What it means
The first new fibromyalgia medicine in more than 15 years, and the fourth approved. The average benefit over placebo is modest.
Last reviewed 2026-11-14 by the Find a Trial editorial team.
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