Study summary

Immunotherapy and chemotherapy before surgery shrank tumors enough to save the larynx in every eligible patient

REMATCH trial · Phase 2, single-arm · Published September 2026, Clinical Cancer Research

What was tested

Immunotherapy plus chemotherapy before surgery, followed by smaller, response-adapted surgery, for locally advanced laryngeal and hypopharyngeal cancer.

What they found

• All 39 people with laryngeal or hypopharyngeal cancer who had reduced-volume surgery kept laryngeal function.
• The trial was small and had no comparison group.

What it means

Points to a new route to larynx preservation that needs testing in larger randomized trials.