Study summary

Obinutuzumab helped more people with lupus kidney disease reach full kidney response

REGENCY trial · 271 people, phase 3 · Published February 2025, New England Journal of Medicine; FDA approved 2025

46.4%complete kidney response at 76 weeks, vs 33.1%

What was tested

Obinutuzumab, an antibody that deeply depletes B cells, added to standard therapy, against placebo plus standard therapy, for active lupus nephritis.

What they found

What it means

Adds a third approved drug for lupus nephritis, alongside belimumab and voclosporin.

N Engl J Med, via PubMed ↗ ← Back to the outlook
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.