Study summary

A vaginal postbiotic added to steroids improved symptoms

Postbiotic trial · Randomized, double-blind · Published January 2026, BMC Microbiology

What was tested

Postbiotics from Lactobacillus crispatus bacteria plus steroid cream, against placebo plus steroid cream, for vulvar lichen sclerosus.

What they found

• People with lichen sclerosus had fewer Lactobacillus bacteria than healthy volunteers.
• Adding the postbiotic improved doctor-rated severity and quality of life.

What it means

Small single-center study; points to the vaginal microbiome as a target.