Study summary

Penile cancers linked to HPV had better survival than those that were not

HPV and p16 review · 3,944 men in 34 studies · Published January 2025, JNCCN

What was tested

A pooled look at studies testing penile cancers for HPV, or for p16, a protein that signals HPV involvement, and comparing outcomes.

What they found

• About half of penile cancers worldwide are linked to HPV.
• p16-positive cancers had better overall and disease-specific survival.
• The authors recommend testing for p16 at diagnosis.

What it means

Testing helps predict outlook, and points to HPV vaccination as prevention.