Study summary
Hydrochlorothiazide did not prevent stones from coming back
What was tested
Hydrochlorothiazide at 12.5, 25 or 50 mg daily against placebo for preventing recurrent calcium stones.
What they found
- Stone recurrence did not differ between any dose and placebo.
- Side effects were more common with the drug.
What it means
Challenged a decades-old prevention habit; prevention now focuses on diet, fluids and tailored drugs.
Last reviewed 2026-11-14 by the Find a Trial editorial team.
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