Study summary

The first pill for treating attacks brought relief in under 2 hours

KONFIDENT trial (sebetralstat) · 136 people, phase 3 · Published May 2024, New England Journal of Medicine; FDA approved 2025

1.61hours median to symptom relief, vs 6.72 with placebo

What was tested

Sebetralstat, an oral plasma kallikrein inhibitor taken when an attack starts, against placebo.

What they found

Median time to start of symptom relief was 1.61 hours (300 mg) vs 6.72 hours with placebo.
Attacks resolved completely faster.

What it means

Replaces an injection or infusion with a pill for on-demand treatment.

N Engl J Med, via PubMed ↗ ← Back to the outlook

Last reviewed 2026-11-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.