Study summary

Proton and carbon ion radiation both gave high survival for sacral chordoma

ISAC trial · Randomized trial · Published June 2024, Radiotherapy and Oncology

What was tested

Hypofractionated proton against carbon ion radiotherapy for chordoma of the sacrum and tailbone.

What they found

• 2-year survival was 96% and 4-year survival 81%.
• Smaller tumors and younger age trended toward better survival.

What it means

Both particle types are reasonable for sacral chordoma when surgery is not possible or as an alternative.