Study summary

Bone marrow transplants from half-matched relatives worked for most adults

Half-matched transplant trial · 54 enrolled, phase 2 · Published February 2025, NEJM Evidence

What was tested

Bone marrow transplant from a half-matched (haploidentical) relative, such as a parent or sibling, for adults with severe sickle cell disease.

What they found

• Overall survival was 95.0%; most were cured of sickle cell disease.
• Three people had graft failure.

What it means

Widens transplant to people without a fully matched donor, a cheaper cure than gene therapy where available.