Study summary

Duloxetine worked as well as amitriptyline with fewer side effects

Duloxetine vs amitriptyline trial · Randomized trial · Published July 2025, Lower Urinary Tract Symptoms

What was tested

Duloxetine against amitriptyline for 8 weeks in women with chronic pelvic pain syndrome, measured with the same symptom index used in men.

What they found

• Both improved total symptom scores similarly at 4 and 8 weeks.
• Duloxetine lowered pain scores more; amitriptyline helped urinary symptoms more.
• Fewer people stopped duloxetine because of side effects.

What it means

Supports duloxetine as a better-tolerated option. The trial was in women; results in men may differ.