Study summary
One dose of pharmaceutical LSD eased anxiety for 12 weeks in two trials
11.6 vs 6.2points of improvement on a 56-point anxiety scale, DT120 vs placebo
What was tested
DT120 (formerly MM120), a pharmaceutical form of LSD given once under supervision, against placebo in adults with generalized anxiety disorder.
What they found
- In Voyage, anxiety scores improved by about 11.6 points at 12 weeks with DT120 and 6.2 with placebo.
- In Panorama, the difference from placebo was 5.1 points.
- Both trials used a single dose with no talk-therapy program attached.
- The company plans to apply for approval. No application or approval was found as of November 2026.
- People can usually tell whether they received LSD, which makes placebo comparisons harder to interpret.
What it means
The largest effect seen in an anxiety drug trial in decades, from one dose. It would need supervised dosing sessions.
Last reviewed 2026-11-14 by the Find a Trial editorial team.
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