Study summary
Much less radiation after surgery cut long-term side effects
3%severe long-term side effects, vs 11% with standard treatment
What was tested
De-escalated radiation after transoral surgery (30-36 Gy over 2 weeks with docetaxel), against standard 60 Gy over 6 weeks with cisplatin, for HPV-positive oropharyngeal cancer.
What they found
- Severe chronic side effects at 3-24 months were 3% vs 11%.
- Long-term feeding tube use was 2% vs 8%.
What it means
Shows a much shorter, gentler course is feasible after surgery for well-selected patients.
Last reviewed 2026-11-15 by the Find a Trial editorial team.
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