Study summary
CAR T cells put 9 of 10 people with severe lupus into remission without other drugs
9 of 10people with lupus reached remission
What was tested
Zorpocel, a CD19 CAR T-cell therapy that wipes out B cells and lets the immune system reset, for severe treatment-resistant lupus and other autoimmune diseases.
What they found
- 9 of 10 people with lupus reached remission (DORIS criteria) at 24 weeks.
- Across studies, about 84% of CAR T-treated lupus patients reached drug-free remission, though outcomes are more varied in broader groups.
- Risks include cytokine release syndrome and the need for chemotherapy beforehand.
What it means
Possibly the first route to drug-free remission in severe lupus. Small, uncontrolled studies so far; randomized trials are starting.
Last reviewed 2026-11-14 by the Find a Trial editorial team.
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