Study summary

A brachyury vaccine with radiation did not clearly improve responses

Brachyury vaccine trial · Randomized phase 2 · Published July 2024, Cancer

What was tested

A vaccine targeting brachyury, the protein that drives chordoma, combined with radiation, against radiation alone, for advanced chordoma.

What they found

• Response rates were low and similar with or without the vaccine.

What it means

Brachyury remains the key target, but this vaccine was not enough on its own.