Study summary

Chemotherapy after surgery modestly improved survival for localized sarcoma

Adjuvant chemotherapy meta-analysis · Systematic review and meta-analysis · Published March 2025, Cancer

0.80hazard ratio for death with chemotherapy after surgery

What was tested

A pooled analysis of randomized trials of chemotherapy after surgery for localized, removable soft tissue sarcomas of the limbs and trunk.

What they found

Chemotherapy after surgery lowered the risk of death by about 20% (hazard ratio 0.80).
Disease-free survival also improved (hazard ratio 0.78).

What it means

Supports offering chemotherapy to people at high risk of recurrence; trials now use tumor gene signatures to pick who benefits.

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Last reviewed 2026-11-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.