Study summary

Mitotane and radiation after surgery were each linked to better outcomes

Mitotane and radiation review · Pooled studies · Published October 2024, Urologic Oncology

What was tested

A pooled look at studies of mitotane, an adrenal-targeting pill, and radiation after removal of the adrenal gland for adrenocortical carcinoma. The studies were not randomized.

What they found

Mitotane after surgery was linked to longer time before the cancer returned.
Radiation after surgery was linked to longer survival.
Mitotane looked most helpful when the surgical margins were clear.

What it means

Supports discussing both after surgery. A randomized trial (ADIUVO-2) is testing adding chemotherapy.

Urol Oncol, via PubMed ↗ ← Back to the outlook

Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.