Sponsor or institution

Clinical trials and research at University Health Network

• 16NIH research projects

NIH-funded research (16)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• North American Star Consortium: Advancing Early Therapeutics in Cancer

  A nationwide network of cancer centers is extending support to run early-stage cancer drug trials, helping eligible patients access promising therapies more quickly.

  NIH research University Health Network · Toronto, Canada · NIH-11495520

• Reference values and decision points for swallowing test scans (VF) across adults

  Aims to create reliable age-appropriate reference values for swallowing test scans to improve diagnosis for adults with swallowing problems.

  NIH research University Health Network · Toronto, Canada · NIH-11399787

• Creating access to lung transplant for high-risk candidates

  A national effort aims to improve how people with very high risk, such as those with ARDS or on ECMO, can access life-saving lung transplants and have better outcomes.

  NIH research University Health Network · Toronto, Canada · NIH-11393345

• Wild-like mice to better mirror human immune responses in cancer and immunotherapy

  A grant to develop lab-made “wild-like” mice that have adult-like immune systems to improve how well mouse studies predict human cancer and immune therapies.

  NIH research University Health Network · Toronto, Canada · NIH-11378589

• Liquid biopsy for brain tumors: using DNA methylation in blood to guide brain cancer care

  A study aims to test if measuring DNA methylation patterns in blood can reliably help diagnose brain tumors and monitor treatment without invasive brain surgery.

  NIH research University Health Network · Toronto, Canada · NIH-11319801

• Making donated lungs last longer after transplant

  This project uses gene editing and immune therapies applied to donor lungs during outside-the-body preservation to reduce inflammation and help transplant patients keep their new lungs longer.

  NIH research University Health Network · Toronto, Canada · NIH-11249981

• Expanding lung transplant access for high-risk patients

  This program works to make lung transplants more safely available and improve care for high-risk candidates such as highly sensitized people, patients on ECMO waiting for transplant, and those with ARDS including COVID-related ARDS.

  NIH research University Health Network · Toronto, Canada · NIH-11146564

• Normal ranges and clinical cutoffs for X-ray swallowing tests (videofluoroscopy)

  This project defines normal swallowing measurements from X-ray swallowing tests across adult ages so clinicians can more clearly identify swallowing problems in people such as those with ALS.

  NIH research University Health Network · Toronto, Canada · NIH-11135469

• Why a protein-recycling system causes treatment resistance in small cell lung cancer

  Researchers are looking at whether problems in a protein-recycling complex make small cell lung cancer resistant to platinum chemotherapy and PARP inhibitor drugs, to help people whose cancer returns after treatment.

  NIH research University Health Network · Toronto, Canada · NIH-11135364

• North American Group for New Cancer Treatments

  This group brings together top cancer centers to find new ways to treat cancer through early stage clinical trials.

  NIH research University Health Network · Toronto, Canada · NIH-11074688

• Investigating how gut bacteria affect immune response in pancreatic cancer.

  This study is looking at how the bacteria in our bodies might affect the immune system and tumor growth in pancreatic cancer, and it aims to find ways to boost the effectiveness of current treatments for patients with this condition.

  NIH research University Health Network · Toronto, Canada · NIH-11066513

• Using blood tests to analyze DNA changes in brain tumors for better diagnosis

  This study is looking at a new, simple way to check for brain tumors by analyzing DNA from your blood, so you won't need risky surgeries to get an accurate diagnosis.

  NIH research University Health Network · Toronto, Canada · NIH-11052509

• Improving lung transplant outcomes through advanced donor lung treatment

  This study is looking at new ways to make lung transplants safer and more successful for people with serious lung diseases by using a special method to keep and check donor lungs outside the body, while also using gene editing to improve their quality.

  NIH research University Health Network · Toronto, Canada · NIH-11032872

• Improving access to lung transplants for high-risk patients

  This study is working to make it easier for high-risk patients, like those with severe lung issues or on life support, to get lung transplants by creating clear guidelines to ensure they receive fair treatment and care.

  NIH research University Health Network · Toronto, Canada · NIH-10892173

• Investigating how dolutegravir affects pregnant women and the risk of birth defects.

  This study is looking at how the medication dolutegravir (DTG) affects the health of pregnant women with HIV and their babies, specifically to see if it might be linked to certain birth defects, and it aims to help ensure that DTG is safe for both moms and their little ones.

  NIH research University Health Network · Toronto, Canada · NIH-10840973

• Investigating how a protein-recycling complex affects treatment resistance in small cell lung cancer.

  This study is looking into why some people with small cell lung cancer stop responding to treatments that initially worked well for them, and it's trying to find new ways to improve those treatments by understanding the underlying causes of this resistance.

  NIH research University Health Network · Toronto, Canada · NIH-10684226

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