Sponsor or institution

Clinical trials and research at NRG Oncology

• 21Clinical trials
• 14Countries

Newest trials

All recruiting trials (21)

• Temporally-Modulated Pulsed Radiation Therapy plus TMZ for MGMT-Unmethylated Glioblastoma

  This study tests whether temporally-modulated pulsed radiation therapy plus temozolomide improves outcomes for people with newly diagnosed MGMT-unmethylated, IDH-wildtype glioblastoma.

  Recruiting at 54 sites Phase 3 NRG Oncology · Irvine, California and 53 other locations · NCT07452458

• Radiation plus cetuximab vs radiation plus chemotherapy for advanced head and neck cancer patients who cannot receive cisplatin

  This trial tests whether adding cetuximab to radiation works as well as, or better than, radiation with carboplatin and paclitaxel for people with advanced head and neck cancers who can’t have cisplatin.

  Recruiting at 150 sites Phase 3 NRG Oncology · Birmingham, Alabama and 149 other locations · NCT07441681

• Immunotherapy with or without targeted high-dose liver radiation (SBRT) for advanced liver cancer

  This trial will see if adding targeted high-dose liver radiation (SBRT) to standard immunotherapy helps people with advanced liver cancer that has invaded blood vessels.

  Recruiting at 139 sites Phase 3 NRG Oncology · Berkeley, California and 138 other locations · NCT07166406

• Shorter-course versus standard-course radiation with chemotherapy for muscle-invasive bladder cancer

  This trial tests whether a much shorter course of radiation plus standard chemotherapy works as well as the usual shorter radiation schedule for people with muscle-invasive bladder cancer who are pursuing bladder-preserving treatment.

  Recruiting at 247 sites Phase 3 NRG Oncology · Fairbanks, Alaska and 258 other locations · NCT07097142

• Higher-dose targeted radiation for locally advanced pancreatic cancer

  This tests whether giving a higher, precisely targeted dose of radiation after initial chemotherapy helps people with locally advanced unresectable pancreatic cancer live longer.

  Recruiting at 327 sites Phase 3 NRG Oncology · Gilbert, Arizona and 332 other locations · NCT06958328

• Digital mindfulness programs for life after breast cancer

  This trial will test whether a live Zoom mindfulness class or a self‑paced app can help younger breast cancer survivors with mild-to-moderate depressive symptoms.

  Recruiting at 448 sites Phase 3 NRG Oncology · Phoenix, Arizona and 455 other locations · NCT06748222

• Testing Olaparib with or without Bevacizumab for Ovarian Cancer Treatment

  This study is testing if a new cancer treatment called olaparib, alone or with another drug called bevacizumab, can help women with advanced ovarian cancer live longer without their cancer getting worse.

  Recruiting at 682 sites Phase 3 NRG Oncology · Birmingham, Alabama and 708 other locations · NCT06580314

• Adding BMX-001, a drug that protects normal tissue from radiation damage, to standard chemoradiation for head and neck cancer

  This trial tests whether giving BMX-001 along with usual mouth-care reduces severe mouth sores in people getting cisplatin-based chemoradiation for HPV-related and other head and neck cancers.

  Recruiting at 146 sites Phase 2 NRG Oncology · Gilbert, Arizona and 152 other locations · NCT06532279

• Comparing proton radiation therapy to standard radiation for leptomeningeal metastasis

  This study is testing whether proton radiation therapy is better than standard radiation for people with leptomeningeal metastasis from breast or lung cancer to see if it helps them live longer and stay healthier.

  Recruiting at 58 sites Phase 3 NRG Oncology · Phoenix, Arizona and 57 other locations · NCT06500481

• Comparing different telephone methods for managing symptoms during cancer treatment

  This study is testing three different phone-based support methods to see which one helps cancer patients manage their symptoms and feelings better during treatment.

  Recruiting at 34 sites NRG Oncology · Phoenix, Arizona and 33 other locations · NCT06279013

• Comparing shorter radiation therapy to standard radiation for high-risk prostate cancer

  This study is testing if a shorter, more intense radiation treatment for high-risk prostate cancer can work just as well as the standard longer treatment.

  Recruiting at 431 sites Phase 3 NRG Oncology · Birmingham, Alabama and 435 other locations · NCT05946213

• Evaluating chemotherapy with ovarian suppression and endocrine therapy for premenopausal breast cancer patients

  This study is testing if adding chemotherapy to ovarian suppression and hormone therapy can help younger women with early-stage breast cancer live longer without cancer returning.

  Recruiting at 1145 sites Phase 3 NRG Oncology · Birmingham, Alabama and 1275 other locations · NCT05879926

• Comparing lymph node mapping techniques for endometrial cancer treatment

  This study is testing whether a new way of mapping lymph nodes during surgery for early-stage endometrial cancer can help reduce leg swelling compared to the standard method.

  Recruiting at 45 sites Phase 3 NRG Oncology · Washington D.C., District of Columbia and 59 other locations · NCT05646316

• Adding high dose targeted radiation to usual treatment for advanced lung cancer

  This study is testing if adding a high dose of targeted radiation to the usual chemotherapy and immunotherapy can help people with advanced lung cancer live longer and feel better.

  Recruiting at 446 sites Phase 3 NRG Oncology · Birmingham, Alabama and 476 other locations · NCT05624996

• Comparing treatments for advanced HER2-positive salivary gland cancer

  This study is testing if a new drug called T-DM1 works better than the usual treatment for people with advanced HER2-positive salivary gland cancer, while also looking at another drug for those with lower levels of HER2.

  Recruiting at 143 sites Phase 2 NRG Oncology · Birmingham, Alabama and 153 other locations · NCT05408845

• Combining Stereotactic Radiation with Immune Therapy for Advanced Kidney Cancer

  This study is testing whether adding a special type of radiation therapy to standard immune treatment can help people with advanced kidney cancer live longer and feel better.

  Recruiting at 303 sites Phase 2 NRG Oncology · Birmingham, Alabama and 347 other locations · NCT05327686

• Evaluating chemotherapy based on circulating tumor DNA in colon cancer patients

  This study is testing if checking for tumor DNA in the blood after surgery can help doctors decide the best chemotherapy for people with Stage III colon cancer.

  Recruiting at 964 sites Phase 2/3 NRG Oncology · Birmingham, Alabama and 1084 other locations · NCT05174169

• Comparing 5-year and 10-year colonoscopy schedules for patients with non-advanced adenomas

  This study is testing whether people with 1 to 2 non-advanced polyps can safely have colonoscopies every 10 years instead of every 5 years without raising their risk of colorectal cancer.

  Recruiting at 348 sites NRG Oncology · Fairbanks, Alaska and 498 other locations · NCT05080673

• Reducing radiation for certain early-stage breast cancer patients

  This study tests if certain early-stage breast cancer patients can skip radiation therapy after surgery and still have the same chance of their cancer coming back.

  Recruiting at 726 sites Phase 3 NRG Oncology · Birmingham, Alabama and 831 other locations · NCT04852887

• Sentinel lymph node biopsy versus standard neck dissection for early-stage oral cavity cancer

  This trial tests whether removing only the sentinel lymph nodes instead of doing a full neck dissection helps people with early-stage oral cavity cancer have better neck and shoulder function while keeping cancer control the same.

  Recruiting at 88 sites Phase 2/3 NRG Oncology · Birmingham, Alabama and 106 other locations · NCT04333537

• Comparing two surgical procedures to lower ovarian cancer risk in women with BRCA1 mutations

  This study is testing if a less invasive surgery can lower the risk of ovarian cancer just as well as a more extensive surgery for women with BRCA1 mutations.

  Recruiting at 548 sites NRG Oncology · Birmingham, Alabama and 629 other locations · NCT04251052

Quick answers

How many clinical trials run by NRG Oncology are recruiting right now?

21, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 14 countries. The most sites are in United States (21 trials), Canada (11 trials), Puerto Rico (6 trials), Japan (3 trials), South Korea (3 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 13, Phase 2: 3, Phase 2/3: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

Describe your situation →