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Clinical trials and research at New York State Psychiatric Institute

• 18Clinical trials
• 2Countries

Newest trials

All recruiting trials (18)

• Cobenfy in Schizophrenia: testing dopamine transmission with PET/MRI

  This small, early-stage trial tests three doses of Cobenfy in people with schizophrenia to see if it changes dopamine activity in the brain using PET imaging.

  Recruiting Phase 1/2 New York State Psychiatric Institute · New York, New York · NCT07423546

• Pattern separation in major depressive disorder: adding memantine to an SSRI

  This study tests whether adding extended-release memantine to an SSRI helps people with major depressive disorder see if their memory and brain activity improve and depressive symptoms get better.

  Recruiting Phase 1 New York State Psychiatric Institute · New York, New York · NCT07139834

• Helping adults with OCD find and keep employment

  This study will test whether adding Individual Placement and Support (IPS) to standard vocational help helps unemployed adults with OCD who are getting CBT find and maintain competitive work.

  Recruiting New York State Psychiatric Institute · New York, New York · NCT07124780

• Propranolol for aggression, self-injury, and severe disruptive behaviors in adolescents and adults with autism

  This trial will test whether propranolol can reduce aggression, self-injury, and other severe disruptive behaviors in people with autism aged 12 to 40.

  Recruiting at 2 sites Phase 2 New York State Psychiatric Institute · Staten Island, New York and 1 other locations · NCT07091279

• Smell memory training for people with mild cognitive impairment

  This trial will test whether a home-based smell memory training program helps people aged 55–89 with mild cognitive impairment improve their sense of smell and thinking skills.

  Recruiting New York State Psychiatric Institute · New York, New York · NCT06825403

• Aerobic exercise added to olanzapine‑samidorphan treatment

  This trial will try whether adding four weeks of supervised aerobic exercise to olanzapine‑samidorphan reduces antipsychotic-related weight gain in adults with schizophrenia or bipolar disorders.

  Recruiting Phase 4 New York State Psychiatric Institute · New York, New York · NCT06740890

• Pimavanserin for treating rigid-compulsive symptoms in autism

  This study is testing if a medication called pimavanserin can help young adults with autism who struggle with rigid and compulsive behaviors.

  Recruiting at 2 sites Phase 2 New York State Psychiatric Institute · Lawrence, Kansas and 1 other locations · NCT05999240

• rTMS plus cognitive-behavioral therapy for cocaine use disorder

  This study tests whether adding rapid magnetic brain stimulation to standard CBT helps people with cocaine use disorder reduce use and improve brain connectivity.

  Recruiting New York State Psychiatric Institute · New York, New York · NCT05974202

• High-frequency rTMS to change food choices in anorexia nervosa

  This study will try high-frequency rTMS to the DLPFC to see if it reduces restrictive food choices in adult women hospitalized with anorexia nervosa.

  Recruiting New York State Psychiatric Institute · New York, New York · NCT05918835

• Scaling up e-Connect in Juvenile Probation Settings

  This project tests a plan to expand e-Connect, an evidence-based suicide risk and cross-system linkage program, across nine Indiana counties to see if it can be adopted widely and cost-effectively in juvenile probation settings.

  Recruiting New York State Psychiatric Institute · New York, New York · NCT05541926

• Cash support and children's brain development in Brazil

  This project will test whether giving mothers larger monthly cash payments (about $40 vs $2) for two years helps improve brain development, executive function, and mental health in 7–10-year-old children from low-income families in São Paulo.

  Recruiting New York State Psychiatric Institute · New York, New York and 1 other locations · NCT05477901

• Glutamatergic Mechanisms: Aim 2

  This study will test how different ketamine doses plus an experimental drug (TS-134 or XT) or placebo engage brain glutamate targets in healthy volunteers.

  Recruiting Phase 1 New York State Psychiatric Institute · New York, New York · NCT05401227

• Using clozapine to reduce violence in people with schizophrenia

  This study is testing if the medication clozapine can help reduce violent behavior in adults with schizophrenia or schizoaffective disorder.

  Recruiting at 7 sites Phase 4 New York State Psychiatric Institute · Los Angeles, California and 6 other locations · NCT05208190

• Combining Buprenorphine and XR-Naltrexone for Opioid Use Disorder Treatment

  This study is testing if combining two medications, buprenorphine-naloxone and XR-naltrexone, can help people with opioid use disorder stay in treatment longer, feel less cravings, and improve their mood.

  Recruiting Phase 2/3 New York State Psychiatric Institute · Rockville, Maryland and 1 other locations · NCT05011266

• Relapse Prevention and Habit Change for Anorexia Nervosa

  This program tests a multi-component relapse-prevention package after hospital treatment to see which parts help people with anorexia nervosa maintain weight over six months.

  Recruiting New York State Psychiatric Institute · New York, New York · NCT04810624

• Computer-based therapy for social anxiety disorder

  A computer-based therapy is being tested to see if it helps people with social anxiety disorder feel less anxious in social situations.

  Recruiting New York State Psychiatric Institute · New York, New York · NCT04663724

• Vaccine to treat opioid-use disorder

  This study is testing a new vaccine to see if it can help people with opioid-use disorder by reducing the effects of oxycodone.

  Recruiting Phase 1/2 New York State Psychiatric Institute · Eatontown, New Jersey and 1 other locations · NCT04458545

• Testing glutamate modulators for reducing heavy drinking in individuals with alcohol use disorder

  This study tests if a new medication that affects brain chemicals can help people with alcohol use disorder drink less, especially when combined with therapy.

  Recruiting Phase 2 New York State Psychiatric Institute · New York, New York · NCT04084860

Quick answers

How many clinical trials run by New York State Psychiatric Institute are recruiting right now?

18, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 2 countries. The most sites are in United States (18 trials), Brazil (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 3, Phase 4: 2, Phase 1: 2, Phase 1/2: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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