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Clinical trials and research at Institute of Cancer Research, United Kingdom

• 22Clinical trials
• 5Countries

Newest trials

All recruiting trials (22)

• Understanding how genetic mutations affect cancer treatment response in advanced solid tumours

  This study tests whether mutations found in tumor and blood samples can help predict who will benefit from early-phase cancer treatments.

  Recruiting at 2 sites Institute of Cancer Research, United Kingdom · Sutton and 1 other locations · NCT07737509

• Bexmarilimab plus nivolumab in solid tumors, melanoma, and NSCLC

  This trial tests whether adding bexmarilimab to nivolumab can help people with melanoma, non-small cell lung cancer, or other advanced solid tumors whose cancer stopped responding to immune therapy.

  Recruiting at 2 sites Phase 1/2 Institute of Cancer Research, United Kingdom · Manchester and 1 other locations · NCT07718243

• BALANCE: Understanding Quality of Life for Black and Mixed Men with Prostate Cancer

  This study tests how prostate cancer and its treatments affect quality of life for Black men of African or Caribbean ancestry and men of mixed Black ancestry.

  Recruiting Institute of Cancer Research, United Kingdom · Rotterdam, Arnhem · NCT07529418

• Paxalisib plus temozolomide for malignant brain tumours with PI3K pathway changes

  This trial tests whether adding paxalisib to standard temozolomide helps people with newly diagnosed MGMT-unmethylated glioblastoma whose tumors have PI3K-activating mutations or PTEN loss.

  Recruiting Phase 1/2 Institute of Cancer Research, United Kingdom · Sutton · NCT07391215

• SX-682 combined with apalutamide for advanced prostate cancer no longer responding to hormone therapy.

  This trial will test whether adding SX-682 to apalutamide helps men with metastatic castration‑resistant prostate cancer who have progressed after another next‑generation antiandrogen.

  Recruiting at 4 sites Phase 1/2 Institute of Cancer Research, United Kingdom · Bellinzona and 3 other locations · NCT07002320

• Idetrexed plus olaparib for high-grade serous ovarian cancer

  This trial tests whether combining idetrexed and olaparib helps people with high-grade serous ovarian cancer that is resistant to standard treatments.

  Recruiting Phase 1 Institute of Cancer Research, United Kingdom · Cambridge, Cambridgeshire and 2 other locations · NCT06976892

• Using ultrasound to improve detection of non-alcoholic fatty liver disease

  This study is trying to see if a new ultrasound method can help find non-alcoholic fatty liver disease earlier and more accurately in both healthy people and patients getting liver MRIs.

  Recruiting Institute of Cancer Research, United Kingdom · London, Greater London · NCT06975579

• i4i PRODICT® saliva genetic risk test for prostate cancer in diverse ethnic groups

  This project will test a saliva-based genetic test (i4i PRODICT®) to estimate future prostate cancer risk in people with a prostate aged 40–55 from Black African/Black Caribbean, South Asian/East Asian, and White European backgrounds.

  Recruiting at 3 sites Institute of Cancer Research, United Kingdom · Sutton, Surrey and 2 other locations · NCT06636526

• Combination therapy for malignant brain tumors using avutometinib and defactinib

  This study is testing a new combination of two drugs, avutometinib and defactinib, to see if they can help people with advanced malignant brain tumors like glioblastoma feel better and improve their treatment options.

  Recruiting at 3 sites Phase 1/2 Institute of Cancer Research, United Kingdom · Cambridge and 2 other locations · NCT06630260

• Understanding the role of the microbiome in prostate cancer

  This study is trying to see how the bacteria in our bodies might affect prostate cancer and its treatment by collecting tissue samples from patients with different stages of the disease.

  Recruiting Institute of Cancer Research, United Kingdom · Sutton, Surrey · NCT06423976

• Combining antibiotics with enzalutamide for advanced prostate cancer treatment

  This study is testing whether combining antibiotics with enzalutamide can help men with advanced prostate cancer feel better and fight their disease.

  Recruiting at 2 sites Phase 1/2 Institute of Cancer Research, United Kingdom · Bellinzona and 1 other locations · NCT06126731

• Using SBRT and Niraparib for Ovarian Cancer with Limited Progression

  This study is testing if combining a type of targeted radiation therapy with a cancer medication can help women with advanced ovarian cancer that has only spread a little bit feel better and live longer.

  Recruiting at 7 sites Phase 2 Institute of Cancer Research, United Kingdom · Leeds, Leeds and 6 other locations · NCT05990192

• Research on new treatments for multiple myeloma

  This study is testing new treatments for multiple myeloma by collecting blood and bone marrow samples from patients to find better options with fewer side effects.

  Recruiting Institute of Cancer Research, United Kingdom · Sutton · NCT05968417

• Observing biomarkers in men with prostate cancer on active surveillance

  This study is testing how certain biological markers relate to the progression of prostate cancer in men on active surveillance, focusing on those with different genetic risks.

  Recruiting at 3 sites Institute of Cancer Research, United Kingdom · Sutton, Surrey and 3 other locations · NCT05810467

• Comparing two types of radiotherapy for high-risk localized prostate cancer

  This study is testing whether targeting just the prostate or both the prostate and nearby lymph nodes with a specific type of radiotherapy is safer and more effective for men with high-risk localized prostate cancer.

  Recruiting at 38 sites Phase 3 Institute of Cancer Research, United Kingdom · Cork and 41 other locations · NCT05613023

• Imaging study using FCH-PET-CT in men with prostate cancer and DNA repair gene mutations

  This study is testing if a new type of imaging called FCH-PET-CT can better find cancer spread in men with prostate cancer who have certain gene mutations compared to regular imaging methods.

  Recruiting Institute of Cancer Research, United Kingdom · London, Sutton, Surrey · NCT05097274

• Evaluating a genetic test for prostate cancer risk

  This study is testing a genetic test to see if it can help men at high risk for prostate cancer understand their risk better and make informed decisions about screening and treatment.

  Recruiting Institute of Cancer Research, United Kingdom · Sutton, England · NCT04763317

• Radiotherapy treatment options for men with localized prostate cancer

  This study is testing whether a new way of giving radiation therapy in fewer sessions can safely help men with localized prostate cancer feel better.

  Recruiting Institute of Cancer Research, United Kingdom · Sutton, Surrey · NCT04595019

• Testing new treatments for triple negative breast cancer before and after surgery

  This study is testing new drugs before and after surgery to see if they can help people with triple negative breast cancer that hasn't completely gone away after chemotherapy.

  Recruiting at 3 sites Phase 2 Institute of Cancer Research, United Kingdom · Bournemouth, Dorset and 5 other locations · NCT03740893

• Daily online MRI for improving radiotherapy precision

  This study is testing a new way to use MRI scans during radiotherapy to help doctors target tumors more accurately and protect healthy tissue in patients with adenocarcinoma.

  Recruiting Institute of Cancer Research, United Kingdom · Sutton, Surrey · NCT02973828

• Analyzing outcomes in prostate cancer patients with rare genetic mutations

  This study is testing how prostate cancer patients with rare genetic mutations respond to treatment compared to those without these mutations to find better ways to manage their care.

  Recruiting Institute of Cancer Research, United Kingdom · Sutton, Surrey · NCT02705846

• Germline genetic profiling for targeted prostate cancer screening and treatment

  This study is testing if targeted prostate cancer screening can help men who are at higher genetic risk due to their family history or ethnicity find cancer earlier and improve their treatment options.

  Recruiting Institute of Cancer Research, United Kingdom · Sutton, Surrey · NCT02543905

Quick answers

How many clinical trials run by Institute of Cancer Research, United Kingdom are recruiting right now?

22, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 5 countries. The most sites are in United Kingdom (21 trials), Switzerland (2 trials), Ireland (1 trial), New Zealand (1 trial), Netherlands (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1/2: 5, Phase 2: 2, Phase 3: 1, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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