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Clinical trials and research at Hutchmed

• 10Clinical trials
• 2Countries

Newest trials

All recruiting trials (10)

• HMPL-A830 in solid tumors for adults with unresectable or metastatic cancer

  This first-in-human study tests HMPL-A830 in adults with unresectable or metastatic solid tumors to see how safe it is and how it behaves at varying doses.

  Recruiting at 4 sites Phase 1/2 Hutchmed · Orange, California and 13 other locations · NCT07718581

• HMPL-760 with R‑GemOx versus placebo with R‑GemOx for relapsed or refractory diffuse large B‑cell lymphoma

  This trial will see if adding HMPL‑760 to R‑GemOx helps adults with relapsed or refractory diffuse large B‑cell lymphoma respond better or live longer than R‑GemOx plus placebo.

  Recruiting at 48 sites Phase 3 Hutchmed · Shanghai, Shanghai Municipality and 50 other locations · NCT07409428

• HMPL-A580 for adults with advanced or metastatic solid tumors

  This tests whether HMPL-A580 is safe and might help adults with unresectable advanced or metastatic solid tumors.

  Recruiting at 9 sites Phase 1/2 Hutchmed · Orange, California and 13 other locations · NCT07396584

• HMPL-A251 for adults with advanced or metastatic HER2-expressing solid tumors

  This trial will test a new drug called HMPL-A251 to see if it is safe and helps adults with unresectable or metastatic HER2-expressing solid tumors.

  Recruiting at 11 sites Phase 1/2 Hutchmed · Denver, Colorado and 14 other locations · NCT07228247

• HMPL-306 treatment for gliomas with IDH1 or IDH2 mutations.

  This study will test whether HMPL-306, a drug that blocks mutant IDH1 and IDH2, is safe and shows early benefit in adults with IDH‑mutant gliomas.

  Recruiting Phase 1 Hutchmed · Shanghai, Shanghai Municipality · NCT07025018

• Combining fruquintinib and sintilimab for advanced endometrial cancer treatment

  This study is testing if a new combination of fruquintinib and sintilimab can help people with advanced endometrial cancer who didn't respond to their first treatment feel better compared to standard chemotherapy.

  Recruiting at 3 sites Phase 3 Hutchmed · Beijing, Beijing Municipality and 16 other locations · NCT06584032

• Oral treatment with HMPL-506 for patients with blood cancers

  This study is testing an oral medication called HMPL-506 to see if it can safely help patients with blood cancers like relapsed or refractory Acute Myeloid Leukemia and Acute Lymphocytic Leukemia.

  Recruiting at 13 sites Phase 1 Hutchmed · Changsha and 15 other locations · NCT06387082

• Evaluating HMPL-306 for patients with specific mutations in Acute Myeloid Leukemia

  This study is testing if a new drug called HMPL-306 can help people with specific mutations in Acute Myeloid Leukemia feel better compared to standard chemotherapy.

  Recruiting at 53 sites Phase 3 Hutchmed · Hefei, Anhui and 52 other locations · NCT06387069

• Evaluating a new treatment combination for metastatic pancreatic cancer

  This study is testing a new combination of treatments for people with advanced pancreatic cancer to see if it works better than the standard care they usually receive.

  Recruiting at 52 sites Phase 2/3 Hutchmed · Hefei, Anhui and 51 other locations · NCT06361888

• Evaluating HMPL-453 for advanced intrahepatic cholangiocarcinoma

  This study is testing a new drug called HMPL-453 to see if it helps people with advanced bile duct cancer that has specific genetic changes.

  Recruiting Phase 2/3 Hutchmed · Beijing, Beijing Municipality · NCT04353375

Quick answers

How many clinical trials run by Hutchmed are recruiting right now?

10, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 2 countries. The most sites are in China (10 trials), United States (3 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1/2: 3, Phase 3: 3, Phase 1: 2, Phase 2/3: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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