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Clinical trials and research at Edwards Lifesciences

• 15Clinical trials
• 13Countries

Newest trials

All recruiting trials (15)

• Feasibility of the Edwards APTURE transcatheter shunt for symptomatic HFrEF with high filling pressures

  This early feasibility study tests whether the Edwards APTURE transcatheter shunt is safe and workable for patients with heart failure with reduced ejection fraction and elevated left atrial pressure.

  Recruiting at 2 sites Edwards Lifesciences · Cologne, Germany and 2 other locations · NCT07858799

• TRIFORMIS RESILIA heart valve real-world results in tricuspid disease

  A real-world, observational study to see how the Edwards TRIFORMIS RESILIA tricuspid heart valve performs in adults needing tricuspid valve replacement.

  Recruiting Edwards Lifesciences · Carmel, Indiana · NCT07684313

• KONECT RESILIA Aortic Valved Conduit real-world use in adults needing valve and ascending aorta replacement

  This study tests how the KONECT RESILIA aortic valved conduit performs in adults needing aortic valve and ascending aorta replacement.

  Recruiting at 3 sites Edwards Lifesciences · München, Bavaria and 2 other locations · NCT07619872

• Real-world outcomes of the INSPIRIS RESILIA aortic valve in adults

  This registry will collect real-world data to see how the INSPIRIS RESILIA aortic valve performs in adults undergoing aortic valve replacement.

  Recruiting at 15 sites Edwards Lifesciences · Heidelberg, Baden-Wurttemberg and 14 other locations · NCT07120048

• Long-term follow-up after MITRIS RESILIA mitral valve replacement in China

  This project will collect health outcomes to see if the MITRIS RESILIA mitral valve is safe and works well for adults in China who need a mitral valve replacement.

  Recruiting at 13 sites Edwards Lifesciences · Beijing, Beijing Municipality and 12 other locations · NCT07059793

• Evaluating long-term outcomes of patients with severe Tricuspid Regurgitation treated with the EVOQUE valve

  This study looks at how well the EVOQUE valve works for people with severe Tricuspid Regurgitation over two years compared to those who receive standard treatment.

  Recruiting Edwards Lifesciences · Irvine, California · NCT06833476

• Investigation of the EVOQUE System for Tricuspid Valve Replacement

  This study is testing a new device for replacing the tricuspid valve in people with heart valve problems to see how safe and effective it is.

  Recruiting at 21 sites Edwards Lifesciences · Bad Berka and 22 other locations · NCT06569602

• Evaluating the SAPIEN X4 Heart Valve for Patients with Failing Aortic Bioprosthetic Valves

  This study is testing a new heart valve to see if it can help people with failing aortic bioprosthetic valves feel better and stay healthy.

  Recruiting at 30 sites Edwards Lifesciences · Newport Beach, California and 36 other locations · NCT05172973

• SAPIEN X4 Transcatheter Heart Valve safety and effectiveness in severe aortic stenosis

  This study tests the safety and effectiveness of the Edwards SAPIEN X4/X4S transcatheter heart valve in patients with symptomatic, severe aortic stenosis.

  Recruiting at 31 sites Edwards Lifesciences · La Jolla, California and 64 other locations · NCT05172960

• Innovalve mitral valve replacement system evaluation

  This study is testing a new mitral valve replacement system to see if it is safe and works well for patients with severe mitral valve leakage.

  Recruiting at 19 sites Edwards Lifesciences · Los Angeles, California and 20 other locations · NCT04919980

• Managing moderate aortic stenosis with TAVR or clinical surveillance

  This study is testing whether a new heart valve replacement method called TAVR is safer and more effective than just monitoring people with moderate aortic stenosis.

  Recruiting at 50 sites Edwards Lifesciences · Huntsville, Alabama and 79 other locations · NCT04889872

• Transcatheter valve repair for severe tricuspid regurgitation

  This study is testing a new valve repair system to see if it helps people with severe tricuspid regurgitation feel better compared to just taking their medications.

  Recruiting at 45 sites Edwards Lifesciences · Phoenix, Arizona and 78 other locations · NCT04097145

• Edwards AP TURE transcatheter shunt system for heart failure in adults with reduced ejection fraction

  This study tests whether the Edwards APTURE transcatheter shunt can be safely implanted and help heart failure patients with reduced ejection fraction feel better and have fewer hospital visits.

  Recruiting at 2 sites Edwards Lifesciences · La Jolla, California and 18 other locations · NCT03523416

• Aortic valve replacement using SAPIEN 3 for failing bioprosthetic valves

  This study is testing if the SAPIEN 3 heart valves can safely help patients with failing bioprosthetic aortic valves feel better.

  Recruiting at 30 sites Edwards Lifesciences · Phoenix, Arizona and 50 other locations · NCT03003299

• Evaluation of a heart valve for patients with pulmonary valve dysfunction

  This study tests a new heart valve to see if it can safely help people with problems in their pulmonary valve or right ventricular outflow tract.

  Recruiting at 21 sites Edwards Lifesciences · Birmingham, Alabama and 26 other locations · NCT02744677

Quick answers

How many clinical trials run by Edwards Lifesciences are recruiting right now?

15, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 13 countries. The most sites are in United States (10 trials), Canada (5 trials), Germany (4 trials), Switzerland (2 trials), Australia (2 trials). Each study page lists its sites and which ones are recruiting.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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