Sponsor or institution
Clinical trials and research at Centessa Pharmaceuticals (UK) Limited
As of November 12, 2026, Find a Trial lists 3 clinical trials run by Centessa Pharmaceuticals (UK) Limited that are recruiting, at sites in 4 countries (most in United States (3), Canada (1), Italy (1)). By phase: Phase 1 (2), Phase 2 (1). Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 3Clinical trials
- 4Countries
Newest trials
| Study | Phase | Where | Status | Registered |
|---|---|---|---|---|
| ORX489 safety and dosing in healthy adults ages 18 to 60 | Phase 1 | Lincoln, Nebraska | Recruiting | Feb 17, 2026 |
| Long-term ORX750 treatment for people with narcolepsy or idiopathic hypersomnia | Phase 2 | Auburn, Alabama and 23 other locations | Recruiting | Jul 31, 2025 |
| ORX142 in healthy adults aged 18–80 | Phase 1 | Lincoln, Nebraska and 2 other locations | Recruiting | Jul 24, 2025 |
All recruiting trials (3)
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ORX489 safety and dosing in healthy adults ages 18 to 60
This will test whether ORX489 tablets are safe, well tolerated, and how they are processed in the body in healthy men and women aged 18 to 60.
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Long-term ORX750 treatment for people with narcolepsy or idiopathic hypersomnia
This open-label extension will try continued ORX750 treatment in people with narcolepsy or idiopathic hypersomnia who completed the earlier ORX750 parent study.
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ORX142 in healthy adults aged 18–80
This trial tests ORX142, an orexin-2 receptor agonist, to see if it is safe, well tolerated, and how the body processes it in healthy adults aged 18–80.
Quick answers
How many clinical trials run by Centessa Pharmaceuticals (UK) Limited are recruiting right now?
3, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
In 4 countries. The most sites are in United States (3 trials), Canada (1 trial), Italy (1 trial), Spain (1 trial). Each study page lists its sites and which ones are recruiting.
What phases are they in?
Phase 1: 2, Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.