Sponsor or institution

Clinical trials and research at Blueprint Medicines Corporation

• 6Clinical trials
• 26Countries

Newest trials

All recruiting trials (6)

• First-in-human test of BLU-924 for KRAS-mutant advanced cancers

  This trial tests BLU-924 in adults with KRAS-mutant advanced solid tumors, including PDAC, NSCLC, and CRC, to see if it is safe and may help control cancer.

  Recruiting at 3 sites Phase 1/2 Blueprint Medicines Corporation · Sarasota, Florida and 15 other locations · NCT07629960

• Real-world care and outcomes for people with indolent systemic mastocytosis (ISM)

  This study will see how people with ISM are treated and how they are doing in everyday care, including those taking avapritinib.

  Recruiting at 7 sites Blueprint Medicines Corporation · Aurora, Colorado and 6 other locations · NCT07264959

• Observing avapritinib treatment in people with indolent systemic mastocytosis in Germany

  This study will see if avapritinib helps manage symptoms in people with indolent systemic mastocytosis who are starting the drug as part of routine care in Germany.

  Recruiting at 12 sites Blueprint Medicines Corporation · Berlin and 11 other locations · NCT07255638

• Screening for KIT D816V-mutated mast cell disease in selected groups

  This screening will test whether people with unexplained anaphylaxis, recurrent mast cell activation symptoms, or conditions like hypermobile EDS or POTS carry the KIT D816V mutation.

  Recruiting at 26 sites Blueprint Medicines Corporation · Birmingham, Alabama and 25 other locations · NCT07143669

• Long-term safety evaluation of avapritinib for mastocytosis patients

  This study is testing the long-term safety of avapritinib for patients with mastocytosis who have already benefited from the treatment in a previous study.

  Recruiting at 8 sites Phase 4 Blueprint Medicines Corporation · Edegem and 7 other locations · NCT06748001

• Evaluating BLU-263 for Indolent Systemic Mastocytosis

  This study is testing if a new medication called elenestinib can help people with indolent systemic mastocytosis who aren't getting enough relief from their current treatments.

  Recruiting at 88 sites Phase 2/3 Blueprint Medicines Corporation · Birmingham, Alabama and 87 other locations · NCT04910685

Quick answers

How many clinical trials run by Blueprint Medicines Corporation are recruiting right now?

6, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 26 countries. The most sites are in United States (4 trials), Belgium (3 trials), Germany (3 trials), Italy (2 trials), Netherlands (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2/3: 1, Phase 4: 1, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

Describe your situation →