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Clinical trials and research at Axsome Therapeutics, Inc.

• 9Clinical trials
• 2Countries

Newest trials

All recruiting trials (9)

• NMDA and Sigma-1 combination therapy for smoking cessation with AXS-05

  This phase 3 trial tests whether AXS-05 can help adults quit smoking better than placebo or bupropion.

  Recruiting at 28 sites Phase 3 Axsome Therapeutics, Inc. · Phoenix, Arizona and 27 other locations · NCT07766655

• Solriamfetol for ADHD in teens: see if it helps with focus

  This phase 3 study tests solriamfetol versus placebo in adolescents with ADHD to see if the medication improves symptoms over 6 weeks.

  Recruiting at 31 sites Phase 3 Axsome Therapeutics, Inc. · Dothan, Alabama and 30 other locations · NCT07717892

• Solriamfetol for children with ADHD: a 6-week comparison to placebo

  This trial tests whether solriamfetol can help children aged 6 to under 12 with ADHD, compared to placebo, over six weeks.

  Recruiting at 32 sites Phase 3 Axsome Therapeutics, Inc. · Dothan, Alabama and 31 other locations · NCT07717879

• Solriamfetol for major depression with excessive daytime sleepiness

  This trial will try solriamfetol (Sunosi) to reduce excessive daytime sleepiness in adults with major depressive disorder.

  Recruiting at 40 sites Phase 3 Axsome Therapeutics, Inc. · Tucson, Arizona and 39 other locations · NCT07484217

• Keeping fibromyalgia symptoms controlled with AXS-14 (esreboxetine) after an initial response

  This Phase 3 study will try AXS-14 (esreboxetine) in adults with fibromyalgia who respond to initial open treatment to see if continuing the drug keeps symptoms controlled better than switching to placebo.

  Recruiting at 57 sites Phase 3 Axsome Therapeutics, Inc. · Glendale, Arizona and 56 other locations · NCT07398417

• Evaluating Solriamfetol for Excessive Sleepiness in Shift Workers

  This study is testing if a new medication called solriamfetol can help adults with excessive sleepiness from shift work feel more awake and alert.

  Recruiting at 46 sites Phase 3 Axsome Therapeutics, Inc. · Auburn, Alabama and 48 other locations · NCT06568367

• Investigating Solriamfetol for Binge Eating Disorder

  This study is testing if a new medication called solriamfetol can help adults with binge eating disorder reduce their binge eating episodes and improve their overall symptoms.

  Recruiting at 38 sites Phase 3 Axsome Therapeutics, Inc. · Encino, California and 44 other locations · NCT06413433

• Registry to evaluate the safety of SUNOSI during pregnancy

  This study is trying to see if the medication SUNOSI is safe for pregnant women who have narcolepsy or sleep apnea and how it affects their babies.

  Recruiting at 2 sites Axsome Therapeutics, Inc. · Morrisville, North Carolina and 1 other locations · NCT06413420

• Evaluating AXS-05 for preventing relapse in depression compared to bupropion

  This study is testing if continuing AXS-05 can help prevent depression from coming back better than switching to bupropion in people who have responded well to AXS-05 before.

  Recruiting at 40 sites Phase 4 Axsome Therapeutics, Inc. · Bellflower, California and 39 other locations · NCT06223880

Quick answers

How many clinical trials run by Axsome Therapeutics, Inc. are recruiting right now?

9, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 2 countries. The most sites are in United States (9 trials), Canada (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 7, Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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