ZBP1 signaling and RSV-caused lung disease in kids
Official title: ZBP1 signaling in RSV triggered host defense and pathogenesis
Funded at Washington State University · NIH-11346588 · Data updated 2026-11-12
This grant explores how a cellular alarm system (ZBP1) influences RSV infection and lung inflammation, with the goal of reducing bronchiolitis and asthma risk in children.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington State University NIH-funded |
| Lab location | 1 site (Pullman, United States) |
| Project start | August 6, 2026 |
| Project end | July 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $618,650 |
| NIH project number | 1R01AI198969-01 |
| Project ID | NIH-11346588 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are infants and children with or at risk for RSV-related airway disease, and families concerned about severe RSV outcomes.
✕Less likely to help
Children without RSV infection or without airway disease are less likely to directly benefit.
What this research studies
The project studies how RSV triggers ZBP1-related cell death and inflammation in the lungs, which may drive severe illness in infants and affected children. Researchers will use animal and cellular models to understand the signaling pathways and test how Z-RNA and RSV proteins interact with ZBP1. The findings could identify new targets to prevent lung damage and long-term respiratory problems after RSV infection. This work aims to translate basic insights into strategies that help kids recover better and avoid future airway diseases.
Why it matters
Potential benefit: If successful, it could lead to new approaches to prevent or lessen severe RSV-related lung injury and later asthma risk in children.
How similar studies have gone: Previous work links RSV, cell death pathways, and ZBP1 to inflammation, but this project tests a specific ZBP1–Z-RNA mechanism in RSV and its impact on lungs.
Where this research is happening
-
Washington State University
Pullman, United States Active
Researchers
- Principal investigator: Bose, Santanu — Washington State University
- Study coordinator: Bose, Santanu
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.